Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2019024150) TERNARY TRANSCRIPTION FACTOR AND APPLICATION THEREOF IN MAMMALIAN PROTEIN EXPRESSION SYSTEM
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/024150 International Application No.: PCT/CN2017/098859
Publication Date: 07.02.2019 International Filing Date: 24.08.2017
IPC:
C07K 14/47 (2006.01) ,C07K 19/00 (2006.01) ,C12N 15/66 (2006.01) ,C12N 15/67 (2006.01) ,C12N 15/79 (2006.01) ,C12N 15/87 (2006.01) ,C07K 1/22 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
66
General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
67
General methods for enhancing the expression
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
87
Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
14
Extraction; Separation; Purification
16
by chromatography
22
Affinity chromatography or related techniques based upon selective absorption processes
Applicants:
杭州阿诺生物医药科技股份有限公司 ADLAI NORTYE BIOPHARMA CO., LTD. [CN/CN]; 中国浙江省杭州市 经济技术开发区6号大街452号高科技企业孵化器2号楼21楼 21 Floor, Building No.2, No.452, 6th Street, Hangzhou Eco. & Tech. Development Area Hangzhou, Zhejiang 310018, CN
Inventors:
何南海 HE, Nanhai; CN
路杨 LU, Yang; CN
杨东晖 YANG, Donghui; CN
王骥 WANG, Ji; CN
Agent:
北京格旭知识产权代理事务所(普通合伙) GEXU INTELLECTUAL PROPERTY LAW FIRM; 中国北京市 海淀区北三环西路甲18号院2号楼(中坤广场E座)7层722-1室 Rm. 722-1, Building 2 (E Zone, Zhongkun Plaza), No. A18 North 3rd Ring West Road, Haidian District Beijing 100098, CN
Priority Data:
201710658328.604.08.2017CN
Title (EN) TERNARY TRANSCRIPTION FACTOR AND APPLICATION THEREOF IN MAMMALIAN PROTEIN EXPRESSION SYSTEM
(FR) FACTEUR DE TRANSCRIPTION TERNAIRE ET SON APPLICATION DANS UN SYSTÈME D'EXPRESSION DE PROTÉINE MAMMIFÈRE
(ZH) 三重转录因子及其在哺乳动物蛋白表达系统的应用
Abstract:
(EN) Provided in the present invention are a transcription factor composition comprising transcription factors ELL, AFF and CRTC. A mammalian protein expression system may be obtained by co-transfecting an expression vector comprising a gene encoding the three transcription factors and a target gene expression vector into a cell line. The presence of transcription factors ELL, AFF and CRTC in the expression system promotes the transcription and expression of the target gene and may be applied to the production of mammalian protein.
(FR) La présente invention concerne une composition de facteur de transcription comprenant des facteurs de transcription ELL, AFF et CRTC. La présente invention concerne également un système d'expression de protéine mammifère qui peut être obtenu par co-transfection d'un vecteur d'expression comprenant un gène codant pour les trois facteurs de transcription et un vecteur d'expression génique cible dans une lignée cellulaire. La présence de facteurs de transcription ELL, AFF et CRTC dans le système d'expression favorise la transcription et l'expression du gène cible et peut être appliqué à la production de protéine mammifère.
(ZH) 本发明提供了一种转录因子组合物,其含有转录因子ELL、AFF和CRTC。将含有编码上述三种转录因子的基因的表达载体与目的基因表达载体共同转染到细胞株中可得到哺乳动物蛋白表达系统,该表达系统中转录因子ELL、AFF和CRTC的存在促进了目的基因的转录和表达,可应用于生产哺乳动物蛋白。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)