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1. (WO2019023812) MALARIA VACCINE COMPOSITION AND METHOD
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/023812 International Application No.: PCT/CA2018/050955
Publication Date: 07.02.2019 International Filing Date: 03.08.2018
IPC:
C07K 19/00 (2006.01) ,A61K 39/015 (2006.01) ,A61K 39/385 (2006.01) ,A61P 33/06 (2006.01) ,A61P 37/04 (2006.01) ,C07K 14/445 (2006.01) ,C07K 16/00 (2006.01) ,C07K 16/20 (2006.01) ,C12N 15/62 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
002
Protozoa antigens
015
Hemosporidia antigens, e.g. Plasmodium antigens
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
385
Haptens or antigens, bound to carriers
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33
Antiparasitic agents
02
Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
06
Antimalarials
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
04
Immunostimulants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
44
from protozoa
445
Plasmodium
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
20
from protozoa
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
62
DNA sequences coding for fusion proteins
Applicants:
THE HOSPITAL FOR SICK CHILDREN [CA/CA]; 686 Bay Street, 3rd Floor Toronto, Ontario M5G 0A4, CA
DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ) [DE/DE]; Im Neuenheimer Feld 280 69120 Heidelberg, DE
Inventors:
JULIEN, Jean-Philippe; CA
SCALLY, Stephen; CA
BOSCH, Alexandre; CA
IMKELLER, Katharina; DE
WARDEMANN, Hedda; DE
MURUGAN, Rajagopa; DE
Agent:
LOWTHERS, Erica L.; CA
MCMANUS, Kimberly A.; CA
BARTOSZEWICZ, Lola A.; CA
SINDEN, Kitt; CA
SABETA, Tony; CA
CHEUNG, SuMei; CA
Priority Data:
62/541,21104.08.2017US
Title (EN) MALARIA VACCINE COMPOSITION AND METHOD
(FR) COMPOSITION DE VACCIN CONTRE LE PALUDISME ET PROCÉDÉ ASSOCIÉ
Abstract:
(EN) A fusion protein comprises: an antigen comprising at least a first and a second antibody-binding epitope; and an antibody or fragment thereof specific for at least the first antigen epitope; wherein binding of the antibody or fragment thereof to the first antigen epitope presents the second antigen epitope for binding to an antigen-binding moiety.
(FR) L'invention concerne une protéine de fusion qui comprend : un antigène comprenant au moins un premier et un second épitope de liaison à un anticorps ; et un anticorps ou un fragment de celui-ci spécifique pour au moins le premier épitope d'antigène ; la liaison de l'anticorps ou du fragment de celui-ci au premier épitope d'antigène présentant le second épitope d'antigène pour une liaison à une fraction de liaison à l'antigène.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)