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1. (WO2019023809) ANTIBODY BINDING ACTIVE ALPHA-SYNUCLEIN
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Pub. No.: WO/2019/023809 International Application No.: PCT/CA2018/050952
Publication Date: 07.02.2019 International Filing Date: 02.08.2018
IPC:
C07K 16/18 (2006.01) ,A61K 39/395 (2006.01) ,A61P 25/28 (2006.01) ,A61P 37/02 (2006.01) ,G01N 33/577 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
577
involving monoclonal antibodies
Applicants:
STRESSMARQ BIOSCIENCES INC. [CA/CA]; Suite 118 (First Floor), 1537 Hillside Avenue Victoria, British Columbia V8T 2C1, CA
Inventors:
LOUWRIER, Ariel; CA
Agent:
SECHLEY, Konrad; CA
ZIESCHE, Sonia; CA
KINGWELL, Brian; CA
WILKE, Mark; CA
THORNE, Lisa; CA
RIPLEY, Roch; CA
LEE, Brian; CA
FERANCE, Stephen; CA
SALISBURY, Clare; CA
Priority Data:
62/540,43502.08.2017US
Title (EN) ANTIBODY BINDING ACTIVE ALPHA-SYNUCLEIN
(FR) ANTICORPS SE LIANT À L'ALPHA-SYNUCLÉINE ACTIVE
Abstract:
(EN) A monoclonal antibody that binds α-synuclein, and that binds tau fibrils, and methods of using the monoclonal antibody, are provided. The monoclonal antibody may be hybridoma clone 2F11. Also provided is a composition comprising the monoclonal antibody 2F11 and a pharmaceutically acceptable carrier, adjuvant, vehicle or excipient. A method of reducing active α-synuclein in a subject in need thereof is also disclosed. The method involves administering an amount of the composition comprising 2F11 to the subject. The monoclonal antibody 2F11 may also be used to determine the α-synuclein, or tau fibril, level in a biological sample.
(FR) L'invention concerne un anticorps monoclonal qui se lie à l'α-synucléine et qui se lie aux fibrilles tau, et des procédés d'utilisation de l'anticorps monoclonal. L'anticorps monoclonal peut être un clone d'hybridome 2F11. L'invention concerne également une composition comprenant l'anticorps monoclonal 2F11 et un support, un adjuvant, un véhicule ou un excipient pharmaceutiquement acceptable. L'invention porte également sur un procédé de réduction de l'α-synucléine active chez un sujet qui en a besoin. Le procédé consiste en l'administration au sujet d'une quantité de la composition comprenant 2F11. L'anticorps monoclonal 2F11 peut également être utilisé en vue de déterminer le niveau d'α-synucléine, ou de la fibrille tau, dans un échantillon biologique.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)