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1. (WO2019023790) BIOMARKERS IN EX VIVO LUNG PERFUSION (EVLP) PERFUSATE
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Pub. No.: WO/2019/023790 International Application No.: PCT/CA2018/050922
Publication Date: 07.02.2019 International Filing Date: 30.07.2018
IPC:
G01N 33/48 (2006.01) ,A61B 5/00 (2006.01) ,G01N 33/53 (2006.01) ,G01N 33/543 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
5
Measuring for diagnostic purposes; Identification of persons
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
543
with an insoluble carrier for immobilising immunochemicals
Applicants:
UNIVERSITY HEALTH NETWORK [CA/CA]; 190 Elizabeth Street R. Fraser Elliott Building - Room 1S-417 Toronto, Ontario M5G 2C4, CA
Inventors:
KESHAVJEE, Shafique; CA
LIU, Mingyao; CA
CYPEL, Marcelo; CA
SAGE, Andrew; CA
Agent:
BERESKIN & PARR LLP/S.E.N.C.R.L., S.R.L.; 40th Floor 40 King Street West Toronto, Ontario M5H 3Y2, CA
Priority Data:
62/539,37331.07.2017US
62/654,73809.04.2018US
Title (EN) BIOMARKERS IN EX VIVO LUNG PERFUSION (EVLP) PERFUSATE
(FR) BIOMARQUEURS DANS UN PERFUSAT DE PERFUSION PULMONAIRE EX VIVO (EVLP)
Abstract:
(EN) Methods and kits for screening, diagnosing, detecting or predicting a patient outcome/risk variable for a lung transplant recipient after transplant or an EVLP outcome by measuring biomarker levels of one or more biomarkers selected from IL-6, IL-8, sTNFR1 and sTREM-1 in EVLP perfusate are described. The methods involve for example, i. obtaining one or more test EVLP perfusate samples of a donor lung; ii. determining in one or more test EVLP perfusate sample of a donor lung, a polypeptide level of one or more biomarkers selected from IL-8, IL-6, sTNFR1 and sTREM-1; and iii. a) comparing the polypeptide level of the one or more biomarkers in the perfusate sample with a control or cut-off level, wherein the differential level is indicative of outcome/risk of after transplant or of an EVLP outcome; or b) using the polypeptide level of one or several of the one or more biomarkers in combination, as part of an algebraic calculation of outcome/risk.
(FR) La présente invention concerne des procédés et des kits destinés à la sélection, au diagnostic, à la détection ou à la prédiction du résultat/risque variable d'un patient pour un receveur de greffe pulmonaire après une greffe ou un résultat d'EVLP par la mesure des niveaux de biomarqueurs d'un ou plusieurs biomarqueurs sélectionnés parmi IL -6, IL -8, sTNFR1 et sTREM-1 dans un perfusat d'EVLP. Les procédés impliquent, par exemple, l'obtention d'un ou plusieurs échantillons de test de perfusat d'EVLP d'un poumon donneur ; ii. la détermination dans un ou plusieurs échantillons de test de perfusat d'EVLP d'un poumon donneur, un niveau polypeptidique d'un ou plusieurs biomarqueurs sélectionnés parmi IL -8, IL -6, sTNFR1 et sTREM-1 ; et iii. a) la comparaison du niveau de polypeptide du ou des biomarqueurs dans échantillon de perfusat avec un niveau de contrôle ou de coupure, le niveau différentiel indiquant le résultat/risque d'après une greffe ou d'un résultat d'EVLP ; ou b) à l'aide du niveau de polypeptide d'un ou plusieurs du ou des biomarqueurs en combinaison, en tant que partie d'un calcul algébrique du résultat/risque.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)