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1. (WO2019023761) TREATMENT OF BONE MARROW PATHOLOGIES WITH POLYSULFATED POLYSACCHARIDES
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Pub. No.: WO/2019/023761 International Application No.: PCT/AU2018/050816
Publication Date: 07.02.2019 International Filing Date: 06.08.2018
IPC:
A61K 31/737 (2006.01) ,A61P 19/08 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
715
Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
737
Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
08
for bone diseases, e.g. rachitism, Paget's disease
Applicants:
PARADIGM BIOPHARMACEUTICALS LTD [AU/AU]; Suite 1, Level 2 517 Flinders Lane Melbourne, Victoria 3000, AU
Inventors:
KRISHNAN, Ravi; AU
RENNIE, Paul; AU
Agent:
FB RICE; Level 23, 44 Market Street Sydney, New South Wales 2000, AU
Priority Data:
201790309404.08.2017AU
Title (EN) TREATMENT OF BONE MARROW PATHOLOGIES WITH POLYSULFATED POLYSACCHARIDES
(FR) TRAITEMENT DE PATHOLOGIES MÉDULLAIRES AVEC DES POLYSACCHARIDES POLYSULFATÉS
Abstract:
(EN) The present invention relates to the medical use of polysulfated polysaccharides and compositions thereof for the treatment of disease or disorders associated with bone marrow pathologies in the musculoskeletal system of a mammal. In particular, the invention relates to use of polysulfated polysaccharides, such as pentosan polysulfate, in treatment of bone marrow edema lesions or spinal Modic Endplate Changes as assessed by magnetic resonance imaging (MRI).
(FR) La présente invention concerne l'utilisation médicale de polysaccharides polysulfatés et de compositions de ceux-ci pour le traitement d'une maladie ou de troubles associés à des pathologies médullaires dans le système musculo-squelettique d'un mammifère. L'invention concerne en particulier l'utilisation de polysaccharides polysulfatés, tels que le polysulfate de pentosane, dans le traitement de lésions d’œdème médullaire ou de changements de plateau vertébral de type Modic évalués par imagerie par résonance magnétique (IRM).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)