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1. WO2019018406 - METHODS FOR THE PURIFICATION OF L-GLUFOSINATE

Publication Number WO/2019/018406
Publication Date 24.01.2019
International Application No. PCT/US2018/042503
International Filing Date 17.07.2018
IPC
A01N 57/20 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
57Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
18having phosphorus-to-carbon bonds
20containing acyclic or cycloaliphatic radicals
B01D 15/36 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
08Selective adsorption, e.g. chromatography
26characterised by the separation mechanism
36involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
G01N 23/207 2018.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
23Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/-G01N17/178
20by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials
207Diffractometry, e.g. using a probe in a central position and one or more displaceable detectors in circumferential positions
CPC
A01N 57/20
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
57Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
18having phosphorus-to-carbon bonds
20containing acyclic or cycloaliphatic radicals
B01D 15/1821
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents
08Selective adsorption, e.g. chromatography
10characterised by constructional or operational features
18relating to flow patterns
1814recycling of the fraction to be distributed
1821Simulated moving beds
B01D 15/34
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents
08Selective adsorption, e.g. chromatography
26characterised by the separation mechanism
34Size selective separation, e.g. size exclusion chromatography, gel filtration, permeation
B01D 15/361
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents
08Selective adsorption, e.g. chromatography
26characterised by the separation mechanism
36involving ionic interaction
361Ion-exchange
C07F 9/535
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
28with one or more P—C bonds
535Organo-phosphoranes
Applicants
  • AGRIMETIS, LLC [US]/[US]
Inventors
  • FIELDS, Stephen Craig
  • OBERHOLZER, Matthew Richard
  • GREEN, Brian Michael
  • KULKARNI, Samir
  • NELSON, Jennifer
  • ANDRES, Patricia
Agents
  • PRESLEY, Andrew D.
  • ROTHSCHILD, Cynthia B.
  • DAVIS, Kimberlynn B.
Priority Data
62/533,94418.07.2017US
62/653,73606.04.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR THE PURIFICATION OF L-GLUFOSINATE
(FR) PROCÉDÉS DE PURIFICATION DE L-GLUFOSINATE
Abstract
(EN)
Compositions and methods for isolating L-glufosinate from a composition comprising L-glufosinate and glutamate are provided. The method comprises converting the glutamate to pyroglutamate followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The composition comprising L-glufosinate and glutamate is subjected to an elevated temperature for a sufficient time to allow for the conversion of glutamate to pyroglutamate, followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The glutamate alternatively may be converted to pyroglutamate by enzymatic conversion. The purified L-glufosinate is present in a final composition at a concentration of 90% or greater of the sum of L-glufosinate, glutamate, and pyroglutamate. In some embodiments, a portion of the glutamate in the starting composition may be separated from the L-glufosinate using a crystallization step. Solid forms of L-glufosinate materials, including crystalline L-glufosinate ammonium, are also described.
(FR)
L'invention concerne des compositions et des procédés d'isolement de L-glufosinate à partir d'une composition comprenant du L-glufosinate et du glutamate. Le procédé comprend la conversion du glutamate en pyroglutamate, suivie par l'isolement de L-glufosinate à partir du pyroglutamate et d'autres composants de la composition pour obtenir du L-glufosinate sensiblement purifié. La composition comprenant du L-glufosinate et du glutamate est soumise à une température élevée pendant un temps suffisant pour permettre la conversion de glutamate en pyroglutamate, suivie par l'isolement de L-glufosinate à partir du pyroglutamate et d'autres composants de la composition pour obtenir du L-glufosinate sensiblement purifié. Selon une autre possibilité, le glutamate peut être converti en pyroglutamate par conversion enzymatique. Le L-glufosinate purifié est présent dans une composition finale à une concentration de 90 % ou plus de la somme de L-glufosinate, de glutamate et de pyroglutamate. Dans certains modes de réalisation, une partie du glutamate dans la composition de départ peut être séparée du L-glufosinate à l'aide d'une étape de cristallisation. L'invention concerne également des formes solides de matériaux L-glufosinate, incluant du L-glufosinate d'ammonium cristallin.
Also published as
IN202037001259
JP2020502197
MXMX/a/2020/000503
Latest bibliographic data on file with the International Bureau