WO2019016111 METHOD FOR PREPARATION OF CHLORINATED S-PROPYLTHIOBARBITURIC ACID

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Publication Number WO/2019/016111

Publication Date 24.01.2019

International Application No. PCT/EP2018/069193

International Filing Date 16.07.2018

IPC

CPC

Applicants

LONZA LTD [CH]/[CH]

Inventors

BERSIER, Michael
HANSELMANN, Paul
STOFFEL, Candid

Priority Data

17181961.8		18.07.2017		EP
62/533,838		18.07.2017		US

Publication Language English (en)

Filing Language English (EN)

Designated States

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Title

(EN) METHOD FOR PREPARATION OF CHLORINATED S-PROPYLTHIOBARBITURIC ACID

(FR) PROCÉDÉ DE PRÉPARATION D'ACIDE S-PROPYLTHIOBARBITURIQUE CHLORÉ

Abstract

(EN) The invention discloses a method for preparation of 4,6-dichloro-5-nitro-2- (propylthio)pyrimidine by conversion of 5-nitro-2-propylthiopyrimidine-4,6-diol with phosgene in the presence of DMF.

(FR) L'invention concerne un procédé de préparation de 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine par conversion de 5-nitro-2-propylthiopyrimidine-4,6-diol avec du phosgène en présence de DMF.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
239	Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02	not condensed with other rings
24	having three or more double bonds between ring members or between ring members and non-ring members
28	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46	Two or more oxygen, sulfur or nitrogen atoms
47	One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
239	Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02	not condensed with other rings
24	having three or more double bonds between ring members or between ring members and non-ring members
28	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46	Two or more oxygen, sulfur or nitrogen atoms
47	One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
239	Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02	not condensed with other rings
24	having three or more double bonds between ring members or between ring members and non-ring members
28	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
30	Halogen atoms or nitro radicals

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
239	Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02	not condensed with other rings
24	having three or more double bonds between ring members or between ring members and non-ring members
28	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46	Two or more oxygen, sulfur or nitrogen atoms
47	One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
239	Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02	not condensed with other rings
24	having three or more double bonds between ring members or between ring members and non-ring members
28	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
30	Halogen atoms or nitro radicals

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1. WO2019016111 - METHOD FOR PREPARATION OF CHLORINATED S-PROPYLTHIOBARBITURIC ACID