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1. (WO2019009956) FE/CU-MEDIATED KETONE SYNTHESIS
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Pub. No.: WO/2019/009956 International Application No.: PCT/US2018/031765
Publication Date: 10.01.2019 International Filing Date: 09.05.2018
IPC:
C07F 7/18 (2006.01) ,C07C 45/00 (2006.01) ,C07C 49/255 (2006.01) ,C07D 319/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
7
Compounds containing elements of the 4th Group of the Periodic System
02
Silicon compounds
08
Compounds having one or more C-Si linkages
18
Compounds having one or more C-Si linkages as well as one or more C-O-Si linkages
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
45
Preparation of compounds having CO groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
49
Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
20
Unsaturated compounds containing keto groups bound to acyclic carbon atoms
255
containing ether groups, groups, groups, or groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
319
Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
04
1,3-Dioxanes; Hydrogenated 1,3-dioxanes
06
not condensed with other rings
Applicants:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street Cambridge, MA 02138, US
Inventors:
KISHI, Yoshito; US
YAHATA, Kenzo; JP
KUMAR, Vemula, Praveen; US
VADDELA, Sudheer, Babu; US
Agent:
HAMZIK, Philip, J.; US
Priority Data:
2017-21725510.11.2017JP
62/529,32606.07.2017US
62/584,32910.11.2017US
Title (EN) FE/CU-MEDIATED KETONE SYNTHESIS
(FR) SYNTHÈSE DE CÉTONE MÉDIÉE PAR FE/CU
Abstract:
(EN) Provided herein are methods for preparing ketone-containing organic molecules. The methods are based on novel iron/copper-mediated ("Fe/Cu-mediated") coupling reactions. The Fe/Cu-mediated coupling reaction can be used in the preparation of complex molecules, such as halichondrins and analogs thereof. In particular, the Fe/Cu-mediated ketolization reactions described herein are useful in the preparation of intermediates en route to halichondrins.
(FR) L'invention concerne des procédés de préparation de molécules organiques contenant de la cétone. Les procédés se basent sur de nouvelles réactions de couplage médiées par fer/cuivre ("médiées par Fe/Cu"). La réaction de couplage médiée par Fe/Cu peut être utilisée dans la préparation de molécules complexes, telles que des halichondrines et analogues de celles-ci. En particulier, les réactions de cétolisation médiées par Fe/Cu ci-décrites sont utiles dans la préparation d'intermédiaires en route vers les halichondrines.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)