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1. (WO2019009793) METHOD FOR ASSESSING SUSCEPTIBILITY OF A VIRUS TO TREATMENT BY MEASURING ENZYME ACTIVITY AND A SYSTEM THEREFORE
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Pub. No.: WO/2019/009793 International Application No.: PCT/SE2018/050726
Publication Date: 10.01.2019 International Filing Date: 03.07.2018
IPC:
C12Q 1/00 (2006.01) ,C12Q 1/48 (2006.01) ,C12Q 1/70 (2006.01) ,G01N 33/94 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
48
involving transferase
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
70
involving virus or bacteriophage
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
94
involving narcotics
Applicants:
CAVIDI AB [SE/SE]; . Virdings Allé 2 754 50 Uppsala, SE
Inventors:
ENQVIST, Stina; SE
KÄLLANDER, Clas; SE
GATU, Tommy; SE
MALMSTEN, Anders; SE
PETTERSSON, Ingvar; SE
Agent:
ZACCO SWEDEN AB; P.O. Box 5581 Valhallavägen 117N 114 85 Stockholm, SE
RYSTEDT, Hampus; SE
Priority Data:
1750874-804.07.2017SE
Title (EN) METHOD FOR ASSESSING SUSCEPTIBILITY OF A VIRUS TO TREATMENT BY MEASURING ENZYME ACTIVITY AND A SYSTEM THEREFORE
(FR) PROCÉDÉ D'ÉVALUATION DE LA SENSIBILITÉ D'UN VIRUS À UN TRAITEMENT PAR MESURE DE L'ACTIVITÉ ENZYMATIQUE ET SYSTÈME ASSOCIÉ
Abstract:
(EN) The present invention relates to a method for assessing susceptibility of a virus to treatment with a drug inhibiting an enzyme of the wild-type virus comprising the steps: a)extracting the viral enzyme from a sample containing the virus; b) measuring the viral enzyme activity both in the absence of the drug and in the presence of the drug at a single predetermined concentration; and c) determining the virus' susceptibility to treatment with the drug from the relation between the enzyme activities in the presence of the drug and the absence of the drug.The invention further relates to a system for performing the method.
(FR) La présente invention concerne un procédé d'évaluation de la sensibilité d'un virus à un traitement par un médicament inhibant une enzyme du virus de type sauvage, le procédé comprenant les étapes consistant : a) à extraire l'enzyme virale dans un échantillon contenant le virus; b) à mesurer l'activité enzymatique virale tant en l'absence du médicament et qu'en présence du médicament à une concentration prédéfinie unique; et c) à déterminer la sensibilité du virus à un traitement par le médicament à partir de la relation entre les activités enzymatiques en présence du médicament et en l'absence du médicament. L'invention concerne en outre un système destiné à mettre en œuvre le procédé.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)