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1. (WO2019009370) AMIDE DERIVATIVE

Pub. No.:    WO/2019/009370    International Application No.:    PCT/JP2018/025564
Publication Date: Fri Jan 11 00:59:59 CET 2019 International Filing Date: Fri Jul 06 01:59:59 CEST 2018
IPC: C07F 5/02
A61K 31/545
A61K 31/69
A61P 31/04
Applicants: SUMITOMO DAINIPPON PHARMA CO., LTD.
大日本住友製薬株式会社
Inventors: KANAI Toshio
金井 利夫
MIZUSHIMA Shingo
水嶋 真吾
Title: AMIDE DERIVATIVE
Abstract:
The purpose of the invention is to find a novel compound having an excellent β-lactamase inhibitory action, and to provide a useful prophylactic or therapeutic agent for bacterial infectious diseases, as a sole agent or in combination with a β-lactam medicine. Disclosed is a compound represented by formula (1a) or (1b), or a pharmaceutically acceptable salt thereof. (In formulas (1a) and (1b), X represents an oxygen atom, a sulfur atom, or -NRa1-; Z represents a hydroxyl group, a C1-6 alkoxy group that may optionally be substituted, or -NRa2Rb1; Ra1, Ra2, and Rb1 are as defined in the Description; L represents a C1-6 alkylene group that may optionally be substituted; Y represents C(=O)NRd1Rd2 wherein Rd1 and Rd2 together form a 4 to 20-membered nitrogen-containing non-aryl hetero ring that may optionally be substituted and that includes, in the ring, the nitrogen atom constituting the amide bond of said Y; and R1, R2, R3, and R4 are as defined in the Description.)