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1. (WO2019009231) DIAGNOSTIC OF RHEUMATOID ARTHRITIS
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Pub. No.: WO/2019/009231 International Application No.: PCT/JP2018/025020
Publication Date: 10.01.2019 International Filing Date: 02.07.2018
IPC:
G01N 33/68 (2006.01) ,C07K 16/38 (2006.01) ,G01N 27/62 (2006.01) ,G01N 33/53 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
38
against protease inhibitors of peptide structure
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27
Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
62
by investigating the ionisation of gases; by investigating electric discharges, e.g. emission of cathode
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
Applicants:
国立大学法人筑波大学 UNIVERSITY OF TSUKUBA [JP/JP]; 茨城県つくば市天王台一丁目1番1 1-1-1, Tennodai, Tsukuba-shi, Ibaraki 3058577, JP
Inventors:
松本 功 MATSUMOTO Isao; JP
住田 孝之 SUMIDA Takayuki; JP
川口 星美 KAWAGUCHI Hoshimi; JP
Agent:
特許業務法人平木国際特許事務所 HIRAKI & ASSOCIATES; 東京都港区愛宕二丁目5-1 愛宕グリーンヒルズMORIタワー32階 Atago Green Hills MORI Tower 32F, 5-1, Atago 2-chome, Minato-ku, Tokyo 1056232, JP
Priority Data:
2017-13288806.07.2017JP
2018-00503816.01.2018JP
Title (EN) DIAGNOSTIC OF RHEUMATOID ARTHRITIS
(FR) DIAGNOSTIC DE LA POLYARTHRITE RHUMATOÏDE
(JA) 関節リウマチ診断薬
Abstract:
(EN) Provided are: a method for diagnosis of rheumatoid arthritis in a subject; a method for auxiliary diagnosis of rheumatoid arthritis; and a method for monitoring disease activity of rheumatoid arthritis and/or a therapeutic effect of a rheumatoid arthritis drug, each method being characterized by comprising detecting citrullination of an arginine residue in inter-α-trypsin inhibitor heavy chain (ITIH) 4 in a biological sample derived from the subject. Also provided are: a citrullinated protein, wherein, in a protein having the amino acid sequence represented by SEQ ID NO: 1 or 5, the 438-th arginine residue has been modified into a citrulline residue, or a fragment of said protein; an antibody capable of binding to the citrullinated protein; and a diagnostic of rheumatoid arthritis which comprises the antibody.
(FR) L'invention concerne : un procédé de diagnostic de la polyarthrite rhumatoïde chez un sujet ; un procédé de diagnostic auxiliaire de la polyarthrite rhumatoïde ; et un procédé de surveillance de l'activité pathologique de la polyarthrite rhumatoïde et/ou de l'effet thérapeutique d'un médicament contre la polyarthrite rhumatoïde, chaque procédé étant caractérisé en ce qu'il comprend la détection de la citrullination d'un résidu arginine dans une chaîne lourde d'un inhibiteur inter-α-trypsine (ITIH) 4 dans un échantillon biologique prélevé chez le sujet. L'invention concerne également : une protéine citrullinée, c'est-à-dire une protéine présentant la séquence d'acides aminés représentée par SEQ ID NO : 1 ou 5, dans laquelle le 438ième résidu arginine a été transformé en un résidu citrulline, ou en un fragment de ladite protéine ; un anticorps capable de se lier à la protéine citrullinée ; et un diagnostic de la polyarthrite rhumatoïde qui implique l'anticorps.
(JA) 本発明は、被験体由来の生物学的サンプル中のインターαトリプシンインヒビター重鎖(ITIH)4のアルギニン残基のシトルリン化を検出することを特徴とする、被験体における関節リウマチを診断する方法、関節リウマチの診断を補助する方法、及び関節リウマチの疾患活動性及び/又は関節リウマチ薬に対する治療効果のモニタリング方法を提供する。本発明はまた、配列番号1若しくは5に示すアミノ酸配列を有するタンパク質において、438番目のアルギニン残基がシトルリン残基に改変されたシトルリン化タンパク質又はその断片、該シトルリン化タンパク質に結合する抗体、及び該抗体を含む関節リウマチ診断薬を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)