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1. (WO2019008574) COMPOUNDS AND METHODS FOR TRANS-MEMBRANE DELIVERY OF MOLECULES
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Pub. No.: WO/2019/008574 International Application No.: PCT/IL2018/050714
Publication Date: 10.01.2019 International Filing Date: 02.07.2018
IPC:
A61K 31/713 (2006.01) ,A61K 47/28 (2006.01) ,A61K 47/48 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
713
Double-stranded nucleic acids or oligonucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
28
Steroids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
Applicants:
APOSENSE LTD. [IL/IL]; 5-7 Haodem Street Kiryat Matalon 49170 Petach-Tikva, IL
Inventors:
ZIV, Ilan; IL
DUBROVSKY, Joseph; IL
GRIMBERG, Hagit; IL
Agent:
GORDON, Irit; IL
Priority Data:
15/641,25104.07.2017US
15/662,66528.07.2017US
15/679,19217.08.2017US
15/691,82131.08.2017US
Title (EN) COMPOUNDS AND METHODS FOR TRANS-MEMBRANE DELIVERY OF MOLECULES
(FR) COMPOSÉS ET PROCÉDÉS POUR L'ADMINISTRATION TRANSMEMBRANAIRE DE MOLÉCULES
Abstract:
(EN) A conjugate for delivery of drugs, such as genetic drugs, [e.g., siRNA, dsiRNA, or antisense oligonucleotides (ASO)] across biological membranes is provided. The conjugates of the Invention are capable of delivering drugs in both presence and absence of plasma proteins.
(FR) L'invention concerne un système de livraison de médicaments, tels que des médicaments génétiques [par ex. l'ARNsi, l'ARNdsi ou des oligonucléotides anti-sens (ASO)] à travers des membranes biologiques. Les conjugués de l'invention sont capables de livrer des médicaments à la fois en présence et en l'absence de protéines plasmatiques.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)