Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2019008554) METHOD FOR THE ORAL TREATMENT AND PREVENTION OF CARDIOVASCULAR DISEASE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/008554 International Application No.: PCT/IB2018/055021
Publication Date: 10.01.2019 International Filing Date: 06.07.2018
IPC:
A61K 38/22 (2006.01) ,C07D 401/02 (2006.01) ,C07D 471/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
22
Hormones
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
Applicants:
CONTE, Anthony [US/US]; US
Inventors:
CONTE, Anthony; US
Agent:
CHOW, Ming; US
Priority Data:
62/529,25706.07.2017US
Title (EN) METHOD FOR THE ORAL TREATMENT AND PREVENTION OF CARDIOVASCULAR DISEASE
(FR) MÉTHODE POUR LE TRAITEMENT ORAL ET LA PRÉVENTION D'UNE MALADIE CARDIOVASCULAIRE
Abstract:
(EN) A method for the oral treatment and prevention of cardiovascular disease utilizes a quantity of non-peptidyl growth hormone secretagogues for: the prophylaxis of atherosclerosis and hypercholesterolemia, preventing the development atherosclerotic plaques and cardiovascular disease; the treatment of pre-existing atherosclerosis or hypercholesterolemia; the reduction of total blood plasma cholesterol levels in a patient's blood; and the expression of genes involved in cellular cholesterol efflux. The quantity of non-peptidyl growth hormone secretagogues is orally administered to the patient. The quantity of non-peptidyl growth hormone secretagogues is selected from the group consisting of ibutamoren mesylate, capromorelin, tabimorelin, and combinations thereof.
(FR) L'invention concerne un procédé pour le traitement oral et la prévention d'une maladie cardiovasculaire utilisant une quantité de sécrétagogues d'hormone de croissance non peptidyle pour : la prophylaxie de l'athérosclérose et de l'hypercholestérolémie, empêchant le développement de plaques d'athérosclérose et de maladie cardiovasculaire; le traitement d'une athérosclérose ou d'une hypercholestérolémie préexistantes; la réduction du taux de cholestérol total dans le plasma sanguin dans le sang du patient; et l'expression de gènes impliqués dans l'efflux de cholestérol cellulaire. La quantité de sécrétagogues d'hormone de croissance non peptidyle est administrée par voie orale au patient. La quantité de sécrétagogues d'hormone de croissance non peptidyle est sélectionnée dans le groupe constitué par le mésylate d'ibutamoren, la capromoréline, la tabimoréline, et des combinaisons de ceux-ci.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)