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1. (WO2019008515) NOVEL HYBRID PEPTIDOMIMETICS FOR USE IN NEUROPATHIC PAIN
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Pub. No.: WO/2019/008515 International Application No.: PCT/IB2018/054925
Publication Date: 10.01.2019 International Filing Date: 03.07.2018
IPC:
C07K 14/665 (2006.01) ,C07K 14/70 (2006.01) ,C07K 14/72 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
665
derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
665
derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
70
Enkephalins
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
72
for hormones
Applicants:
UNIWERSYTET WARSZAWSKI [PL/PL]; Krakowskie Przedmieście 26/28 00-927 Warszawa, PL
INSTYTUT FARMAKOLOGII POLSKIEJ AKADEMII NAUK [PL/PL]; Smetna 12 31-343 Krakow, PL
Inventors:
MISICKA-KESIK, Aleksandra; PL
WITKOWSKA, Ewa; PL
WILENSKA, Beata; PL
PRZEWLOCKA, Barbara; PL
MIKA, Joanna; PL
STARNOWSKA-SOKOŁ, Joanna; PL
PIOTROWSKA-MURZYN, Anna; PL
Agent:
GRANIS-RAFFERTY AGATA; PATPOL Kancelaria Patentowa Sp. z o.o. Nowoursynowska 162J 02-776 Warszawa, PL
Priority Data:
PL42209303.07.2017PL
Title (EN) NOVEL HYBRID PEPTIDOMIMETICS FOR USE IN NEUROPATHIC PAIN
(FR) NOUVEAUX PEPTIDOMIMÉTIQUES HYBRIDES DESTINÉS À ÊTRE UTILISÉS EN CAS DE DOULEUR NEUROPATHIQUE
Abstract:
(EN) The invention pertains to novel hybrid peptidomimetics, pharmaceutical composition comprising thereof and use thereof in the treatment of neuropathic pain. The hybrid peptidomimetics according to the invention are comprised of two components: an opioid receptor agonist (OP) and a MC4 receptor antagonist, connected by a linker. The compounds of such a structure will allow to activate opioid receptors with simultaneous blocking of melanocortin type 4 receptors (MC4), which results in enhancing efficiency of the opioid therapy in neuropathic pain.
(FR) L'invention concerne de nouveaux peptidomimétiques hybrides, une composition pharmaceutique les comprenant et leur utilisation dans le traitement de la douleur neuropathique. Les peptidomimétiques hybrides selon l'invention sont constitués de deux composants : un agoniste du récepteur opioïde (OP) et un antagoniste du récepteur MC4, reliés par un lieur. Les composés d'une telle structure permettent d'activer des récepteurs opioïdes tout en bloquant simultanément les récepteurs de mélanocortine de type 4 (MC4), ce qui permet d'améliorer l'efficacité de la thérapie opioïde en cas de douleur neuropathique.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: Polish (PL)