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1. (WO2019008379) BISPECIFIC ANTIBODIES TO ROR1 AND CD3
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Pub. No.: WO/2019/008379 International Application No.: PCT/GB2018/051916
Publication Date: 10.01.2019 International Filing Date: 05.07.2018
IPC:
C07K 16/28 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
UCL BUSINESS PLC [GB/GB]; The Network Building 97 Tottenham Court Road London W1T 4TP, GB
Inventors:
NATHWANI, Amit; GB
GOHIL, Satyen; GB
DELLA PERUTA, Marco; GB
Agent:
BENTHAM, Andrew; J A Kemp 14 South Square Gray's Inn London WC1R 5JJ, GB
Priority Data:
1710838.205.07.2017GB
Title (EN) BISPECIFIC ANTIBODIES TO ROR1 AND CD3
(FR) ANTICORPS BISPÉCIFIQUES DIRIGÉS CONTRE ROR1 ET CD3
Abstract:
(EN) There is described bispecific antibodies which selectively bind to Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1) and the CD3 subunit of the T-Cell Receptor (TCR), their production and their use. Also described is the use of the bispecific antibodies in the treatment of cancer.
(FR) L'invention concerne des anticorps bispécifiques qui se lient de manière sélective au récepteur 1 orphelin de type récepteur à tyrosine kinase (ROR1) et la sous-unité CD3 du récepteur de lymphocytes T (TCR), ainsi que leur production et leur utilisation. L'invention concerne également l'utilisation des anticorps bispécifiques dans le traitement du cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)