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1. (WO2019008308) POLARISATION TRANSFER VIA A SECOND METAL COMPLEX
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Pub. No.: WO/2019/008308 International Application No.: PCT/GB2018/000103
Publication Date: 10.01.2019 International Filing Date: 03.07.2018
IPC:
G01R 33/28 (2006.01) ,A61K 49/10 (2006.01) ,G01R 33/56 (2006.01) ,C07F 15/00 (2006.01)
G PHYSICS
01
MEASURING; TESTING
R
MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33
Arrangements or instruments for measuring magnetic variables
20
involving magnetic resonance
28
Details of apparatus provided for in groups G01R33/44-G01R33/6496
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
06
Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
08
characterised by the carrier
10
Organic compounds
G PHYSICS
01
MEASURING; TESTING
R
MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33
Arrangements or instruments for measuring magnetic variables
20
involving magnetic resonance
44
using nuclear magnetic resonance (NMR)
48
NMR imaging systems
54
Signal processing systems, e.g. using pulse sequences
56
Image enhancement or correction, e.g. subtraction or averaging techniques
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
15
Compounds containing elements of the 8th Group of the Periodic System
Applicants:
UNIVERSITY OF YORK [GB/GB]; Heslington York Y010 5DD, GB
Inventors:
DUCKETT, Simon; GB
ROY, Soumya Singha; GB
APPLEBY, Kate M.; GB
Agent:
GILHOLM, Stephen Philip; IPheions Intellectual Property The Smithy Office The Hawk Creative Business Park, Easingwold York, North Yorkshire YO61 3FE, GB
Priority Data:
1710677.403.07.2017GB
Title (EN) POLARISATION TRANSFER VIA A SECOND METAL COMPLEX
(FR) TRANSFERT DE POLARISATION PAR L'INTERMÉDIAIRE D'UN SECOND COMPLEXE MÉTALLIQUE
Abstract:
(EN) There is described a method for preparation of an imaging medium via transfer from a hyperpolarised singlet state that is not parahydrogen, said method comprising the steps of: (i) preparing a system containing: parahydrogen; a magnetisation transfer complex, with a molecular symmetry that allows the creation of a singlet state between spin pairs within it, said complex including a reversibly bound small molecule transference substrate; applying a magnetic field such that hyperpolarisation is transferred into the transfer complex, including the reversibly bound small molecule transference substrate; (ii) introducing a recipient complex capable of binding the small molecule transference substrate, said recipient complex including a recipient substrate, such that the recipient complex and recipient substrate, including the bound transference substrate, is hyperpolarised.
(FR) L'invention concerne un procédé de préparation d'un support d'imagerie par transfert depuis un état singulet hyperpolarisé différent du parahydrogène, ledit procédé consistant : (i) à préparer un système contenant : du parahydrogène ; un complexe de transfert d'aimantation, comprenant une symétrie moléculaire qui permet la création d'un état singulet entre des paires de spins à l'intérieur de ce dernier, ledit complexe comprenant un substrat de transfert de petites molécules lié de manière réversible ; à appliquer un champ magnétique de telle sorte que l'hyperpolarisation soit transférée dans le complexe de transfert, comprenant le substrat de transfert de petites molécules lié de manière réversible ; (ii) à introduire un complexe receveur permettant de lier le substrat de transfert de petite molécule, ledit complexe receveur comprenant un substrat receveur, de telle sorte que le complexe receveur et le substrat receveur, comprenant le substrat de transfert lié, sont hyperpolarisés.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)