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1. (WO2019008141) USE OF PHENOTHIAZINE DERIVATIVE IN THE TREATMENT OF INFECTION CAUSED BY BACTERIA CARRYING TYPE IV PILI
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Pub. No.: WO/2019/008141 International Application No.: PCT/EP2018/068393
Publication Date: 10.01.2019 International Filing Date: 06.07.2018
IPC:
C07D 417/06 (2006.01) ,C07D 279/26 (2006.01) ,C07D 279/28 (2006.01) ,A61K 31/5415 (2006.01) ,A61P 31/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
279
Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
10
1,4-Thiazines; Hydrogenated 1,4-thiazines
14
condensed with carbocyclic rings or ring systems
18
[b, e]-condensed with two six-membered rings
22
with carbon atoms directly attached to the ring nitrogen atom
24
with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
26
without other substituents attached to the ring system
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
279
Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
10
1,4-Thiazines; Hydrogenated 1,4-thiazines
14
condensed with carbocyclic rings or ring systems
18
[b, e]-condensed with two six-membered rings
22
with carbon atoms directly attached to the ring nitrogen atom
24
with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
28
with other substituents attached to the ring system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
54
having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
5415
ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) [FR/FR]; 3, rue Michel Ange 75016 PARIS, FR
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) [FR/FR]; 101, rue de Tolbiac 75013 PARIS, FR
UNIVERSITE PARIS DESCARTES [FR/FR]; 12, rue de l'Ecole de Médecine 75006 PARIS, FR
Inventors:
BOURDOULOUS, Sandrine; FR
DENIS, Kévin; FR
LE GUENNEC, Loïc; FR
Agent:
REGIMBEAU; 20, rue de Chazelles 75847 PARIS CEDEX 17, FR
Priority Data:
17305893.407.07.2017EP
Title (EN) USE OF PHENOTHIAZINE DERIVATIVE IN THE TREATMENT OF INFECTION CAUSED BY BACTERIA CARRYING TYPE IV PILI
(FR) UTILISATION D'UN DÉRIVÉ DE PHÉNOTHIAZINE DANS LE TRAITEMENT D'UNE INFECTION PROVOQUÉE PAR DES BACTÉRIES PORTEUSES DE PILI DE TYPE IV
Abstract:
(EN) The present invention provides a phenothiazine derivative of formula (I) for use in preventing and/or treating infection caused by bacteria carrying Type IV pili, such as N.meningitidis,and more specifically for use in preventing and/or treating meningitis. The present invention further relates to a composition for the use in preventing and/or treating infection caused by bacteria carrying Type IV pili, such as purpura fulminans and meningitis, comprising a phenothiazine derivative of formula (I) and an antibiotic selected from the group consisting of beta-lactams and aminoglycosides, and/ or dexamethasone.
(FR) La présente invention concerne un dérivé de phénothiazine de formule (I) destiné à être utilisé dans la prévention et/ou le traitement d'une infection provoquée par des bactéries porteuses de pili de Type IV, telles que N. meningitidis, et plus spécifiquement destiné à être utilisé dans la prévention et/ou le traitement de la méningite. La présente invention concerne en outre une composition destinée à être utilisée dans la prévention et/ou le traitement d'une infection provoquée par des bactéries porteuses de pili de Type IV, telles que purpura fulminans et de la méningite, comprenant un dérivé de phénothiazine de formule (I) et un antibiotique choisi dans le groupe consistant en les bêta-lactames et les aminoglycosides et/ou la dexaméthasone.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)