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1. (WO2019008001) NOVEL NUCLEIC ACID MOLECULES
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Pub. No.: WO/2019/008001 International Application No.: PCT/EP2018/068015
Publication Date: 10.01.2019 International Filing Date: 03.07.2018
IPC:
A61K 39/00 (2006.01) ,A61K 39/39 (2006.01) ,A61K 39/385 (2006.01) ,C07K 14/705 (2006.01) ,C07K 14/465 (2006.01) ,C12N 9/90 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
39
characterised by the immunostimulating additives, e.g. chemical adjuvants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
385
Haptens or antigens, bound to carriers
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
465
from birds
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
90
Isomerases (5.)
Applicants:
CUREVAC AG [DE/DE]; Paul-Ehrlich-Str. 15 72076 Tübingen, DE
Inventors:
FOTIN-MLECZEK, Mariola; DE
FIEDLER, Katja; DE
KOWALCZYK, Aleksandra; DE
HEIDENREICH, Regina; DE
Agent:
VON STOSCH, Andreas; DE
WEISS, Adilka Dorothea; DE
LEHMBACHER, Michael; DE
EICHELBAUM, Kornelia; DE
SCHARPING, Marion; DE
Priority Data:
PCT/EP2017/06667604.07.2017EP
Title (EN) NOVEL NUCLEIC ACID MOLECULES
(FR) NOUVELLES MOLÉCULES D'ACIDE NUCLÉIQUE
Abstract:
(EN) The present invention provides novel artificial nucleic acid molecules encoding at least one antigenic peptide or protein and at least one additional sequence preferably targeting the antigenic peptides or proteins to cellular compartments of interest. Further, the invention provides (pharmaceutical) compositions or vaccines and kits comprising said nucleic acid molecules. The nucleic acid molecules, (pharmaceutical) compositions or vaccines and kits are useful for treating a variety of diseases such as cancer, infectious diseases, autoimmune diseases, allergies or graft-versus host disease.
(FR) La présente invention concerne de nouvelles molécules d'acide nucléique artificielles codant pour au moins un peptide ou une protéine antigénique et au moins une séquence supplémentaire ciblant de préférence les peptides ou protéines antigéniques à des compartiments cellulaires d'intérêt. En outre, l'invention concerne des compositions (pharmaceutiques) ou des vaccins et des kits comprenant lesdites molécules d'acide nucléique. Les molécules d'acide nucléique, les compositions (pharmaceutiques) ou les vaccins et les kits sont utiles pour traiter une variété de maladies telles que le cancer, les maladies infectieuses, les maladies auto-immunes, les allergies ou la maladie du greffon contre l'hôte.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)