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1. (WO2019007996) USE OF MACROAZAPYRIDINOPHANES METAL COMPLEXES IN THE TREATMENT OF DISEASES
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Pub. No.: WO/2019/007996 International Application No.: PCT/EP2018/068010
Publication Date: 10.01.2019 International Filing Date: 03.07.2018
IPC:
A61K 45/06 (2006.01) ,A61K 31/4709 (2006.01) ,A61K 33/26 (2006.01) ,A61K 33/30 (2006.01) ,A61K 33/32 (2006.01) ,A61K 33/34 (2006.01) ,A61P 25/00 (2006.01) ,A61P 25/28 (2006.01) ,A61P 3/08 (2006.01) ,A61P 3/00 (2006.01) ,A61P 31/14 (2006.01) ,A61P 31/18 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
4709
Non-condensed quinolines containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33
Medicinal preparations containing inorganic active ingredients
24
Heavy metals; Compounds thereof
26
Iron; Compounds thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33
Medicinal preparations containing inorganic active ingredients
24
Heavy metals; Compounds thereof
30
Zinc; Compounds thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33
Medicinal preparations containing inorganic active ingredients
24
Heavy metals; Compounds thereof
32
Manganese; Compounds thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33
Medicinal preparations containing inorganic active ingredients
24
Heavy metals; Compounds thereof
34
Copper; Compounds thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
18
for HIV
Applicants:
BIONOS BIOTECH, S.L [ES/ES]; 1ª planta Torre A Hospital La Fe Av. Fernando Abril Martorell 106 46026 Valencia, ES
Inventors:
MULLOR SANJOSÉ, José Luis; ES
VÁZQUEZ MANRIQUE, Rafael; ES
GONZÁLEZ FERNÁNDEZ, David; ES
Agent:
ILLESCAS TABOADA, Manuel; ES
Priority Data:
17382429.304.07.2017EP
Title (EN) USE OF MACROAZAPYRIDINOPHANES METAL COMPLEXES IN THE TREATMENT OF DISEASES
(FR) UTILISATION DE COMPLEXES MÉTALLIQUES DE MACROAZAPYRIDINOPHANES DANS LE TRAITEMENT DE MALADIES
Abstract:
(EN) Metal complexes comprising a compound of general formula (I) and at least one metal ion, for use in the treatment of diseases related to the accumulation of intracellular deposits and/or diseases related to defective autophagy and/or defective proteasome activity is disclosed. C ompositions comprising said metal complexes comprising a compound of general formula (I) and at least one metal ion, for use in the treatment of diseases related to the accumulation of intracellular deposits and/or diseases related to defective autophagy and/or defective proteasome activity are also disclosed.
(FR) L'invention concerne des complexes métalliques comprenant un composé de formule générale (I) et au moins un ion métallique, destinés à être utilisés dans le traitement de maladies liées à l'accumulation de dépôts intracellulaires et/ou de maladies liées à une autophagie défectueuse et/ou à une activité de protéasome défectueuse. L'invention concerne également des compositions comprenant lesdits complexes métalliques comprenant un composé de formule générale (I) et au moins un ion métallique, destinées à être utilisées dans le traitement de maladies liées à l'accumulation de dépôts intracellulaires et/ou de maladies liées à une autophagie défectueuse et/ou à une activité de protéasome défectueuse.
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African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)