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1. (WO2019007664) EF-TU-BINDING ANTIBIOTIC CONTAINING METAL
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Pub. No.: WO/2019/007664 International Application No.: PCT/EP2018/066100
Publication Date: 10.01.2019 International Filing Date: 18.06.2018
IPC:
C07F 13/00 (2006.01) ,A61K 31/4184 (2006.01) ,A61K 31/4188 (2006.01) ,A61P 31/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
13
Compounds containing elements of the 7th Group of the Periodic System
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
4184
condensed with carbocyclic rings, e.g. benzimidazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
4188
condensed with heterocyclic ring systems, e.g. biotin, sorbinil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
Applicants:
RUHR-UNIVERSITÄT BOCHUM [DE/DE]; Universitätsstr. 150 44801 Bochum, DE
Inventors:
METZLER-NOLTE, Nils; DE
SIEGMUND, Daniel; DE
BANDOW, Julia; DE
SCHÄKERMANN, Sina; DE
Agent:
VIERING, JENTSCHURA & PARTNER MBB; Kennedydamm 55/Roßstr. 40476 Düsseldorf, DE
Priority Data:
10 2017 115 215.607.07.2017DE
Title (EN) EF-TU-BINDING ANTIBIOTIC CONTAINING METAL
(FR) ANTIBIOTIQUE CONTENANT DU MÉTAL SE LIANT À LA EF-TU
(DE) EF-TU-BINDENDES METALLHALTIGES ANTIBIOTIKUM
Abstract:
(EN) The invention relates to an N-heterocyclic carbene (NHC) Re(I) complex having an unsubstituted or substituted benzimidazol-2-ylidene ligand and the use thereof, in particular in a pharmaceutical composition, as a medication and for treating a bacterial infection or a bacterial infestation. The invention further relates to a method for producing an N-heterocyclic carbene (NHC) Re(I) complex and to a method for identifying a molecule that interacts with an N-heterocyclic carbene (NHC) Re(I) complex.
(FR) L'invention concerne un complexe N-hétérocyclique de carbène (NHC) Re(l) ayant un ligand benzimidazol-2-ylidène non substitué ou substitué ainsi que son utilisation, notamment dans une composition pharmaceutique, comme médicament et pour le traitement d'une infection ou infestation bactérienne. La présente invention concerne en outre un procédé de préparation d'un complexe N-hétérocyclique de carbène (NHC) Re(l) et un procédé d'identification d'une molécule en interaction avec un complexe N-hétérocyclique de carbène (NHC) Re(l).
(DE) Die Erfindung bezieht sich auf einen N-heterocyclischen Carben (NHC) Re(l) Komplex mit einem unsubstituierten oder substituierten Benzimidazol-2-yliden Liganden und deren Verwendung, insbesondere in einer pharmazeutischen Zusammensetzung, als Medikament und zur Behandlung von einer bakteriellen Infektion oder eines bakteriellen Befalls. Ferner bezieht sich die vorliegende Erfindung auf ein Verfahren zur Herstellung eines N-heterocyclischen Carben (NHC) Re(l) Komplexes und auf ein Verfahren zur Identifizierung eines Moleküls, das mit einem N-heterocyclischen Carben (NHC) Re(l) Komplex interagiert.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: German (DE)
Filing Language: German (DE)