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1. (WO2019007509) NOVEL RECOMBINANT BOTULINUM NEUROTOXINS WITH INCREASED DURATION OF EFFECT
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/007509 International Application No.: PCT/EP2017/066891
Publication Date: 10.01.2019 International Filing Date: 06.07.2017
IPC:
C07K 14/33 (2006.01) ,A61K 38/48 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
33
from Clostridium (G)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
46
Hydrolases (3)
48
acting on peptide bonds (3.4)
Applicants:
MERZ PHARMA GMBH & CO. KGAA [DE/DE]; Eckenheimer Landstr. 100 60318 Frankfurt am Main, DE
Inventors:
FREVERT, Jürgen; DE
HOFMANN, Fred; DE
JURK, Marcel; DE
LÓPEZ DE LA PAZ, Manuela; DE
SCHEPS, Daniel; DE
Agent:
HACKENBERG, Julia; DE
GRAF KEYSERLINGK, Nikolai; DE
Priority Data:
Title (EN) NOVEL RECOMBINANT BOTULINUM NEUROTOXINS WITH INCREASED DURATION OF EFFECT
(FR) NOUVELLES NEUROTOXINES BOTULIQUES RECOMBINANTES PRÉSENTANT UNE DURÉE D'EFFET ACCRUE
(DE) NOVEL RECOMBINANT BOTULINUM NEUROTOXINS WITH INCREASED DURATION OF EFFECT
Abstract:
(EN) This invention relates to novel recombinant botulinum neurotoxins serotype A exhibiting both (i) an increased duration of effect and (ii) a high specific biological activity. These novel recombinant botulinum neurotoxins comprise at least two additional domains consisting of proline, alanine and an additional amino acid residue and at least one amino acid modification which is located at the alpha-exosite or at the beta-exosite of the light chain of the neurotoxin. The invention further relates to novel recombinant single-chain precursor botulinum neurotoxins and compositions comprising the recombinant botulinum neurotoxin with an increased duration of effect and a high specific biological activity.
(FR) La présente invention concerne de nouveaux sérotypes A de neurotoxines botuliques recombinantes présentant à la fois (i) une durée d'effet accrue et (ii) une activité biologique spécifique élevée. Les nouvelles neurotoxines botuliques recombinantes de l'invention comprennent au moins deux domaines supplémentaires constitués de proline, d'alanine et d'un résidu d'acide aminé supplémentaire et au moins une modification d'acide aminé située au niveau de l'exosite alpha ou au niveau de l'exosite bêta de la chaîne légère de la neurotoxine. L'invention concerne en outre de nouvelles neurotoxines botuliques recombinantes précurseurs à chaîne unique et des compositions comprenant la neurotoxine botulique recombinante présentant une durée d'effet accrue et une activité biologique spécifique élevée.
(DE) 45 ABSTRACT This invention relates to novel recombinant botulinum neurotoxins serotype A exhibiting both (i) an increased duration of effect and (ii) a high specific biological activity. These novel recombinant botulinum neurotoxins comprise at least two additional domains consisting of proline, alanine and an additional amino acid residue and at least one amino acid modification which is located at the alpha-exosite or at the beta-exosite of the light chain of the neurotoxin. The invention further relates to novel recombinant single-chain precursor botulinum neurotoxins and compositions comprising the recombinant botulinum neurotoxin with an increased duration of effect and a high specific biological activity.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)