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1. (WO2019007423) IMPLANTABLE APPARATUS
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Pub. No.: WO/2019/007423 International Application No.: PCT/CN2018/094861
Publication Date: 10.01.2019 International Filing Date: 06.07.2018
IPC:
A61L 27/04 (2006.01) ,A61L 27/58 (2006.01) ,A61L 33/02 (2006.01) ,A61L 33/06 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
02
Inorganic materials
04
Metals or alloys
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
50
Materials characterised by their function or physical properties
58
Materials at least partially resorbable by the body
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
33
Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
02
Use of inorganic materials
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
33
Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
06
Use of macromolecular materials
Applicants:
先健科技(深圳)有限公司 LIFETECH SCIENTIFIC (SHENZHEN) CO., LTD [CN/CN]; 中国广东省深圳市 南山区高新技术产业园北区朗山二路赛霸科研楼1-5层 Floor 1-5, Cybio Electronic Building, Langshan 2nd Street, North Area of High-tech Park, Nanshan District Shenzhen, Guangdong 518057, CN
Inventors:
张德元 ZHANG, Deyuan; CN
林文娇 LIN, Wenjiao; CN
秦莉 QIN, Li; CN
陈丽萍 CHEN, Liping; CN
孙宏涛 SUN, Hongtao; CN
Agent:
广州华进联合专利商标代理有限公司 ADVANCE CHINA IP LAW OFFICE; 中国广东省广州市 天河区花城大道85号3901房 Room 3901, No. 85 Huacheng Avenue, Tianhe District Guangzhou, Guangdong 510623, CN
Priority Data:
201710548407.106.07.2017CN
Title (EN) IMPLANTABLE APPARATUS
(FR) APPAREIL IMPLANTABLE
(ZH) 植入式器械
Abstract:
(EN) An implantable apparatus, comprising at least one corrodible zinc-containing portion, wherein a content range of zinc in the at least one zinc-containing portion is [30, 50) wt.% and zinc in the zinc-containing portion is an amorphous structure, or a content range of zinc in the at least one zinc-containing portion is [50, 70] wt.% and a microscopic structure of zinc in the zinc-containing portion is at least one of an amorphous structure, a non-equiaxed structure, an ultrafine-grained structure, or an equiaxed structure with a grain size number of 7 to 14, or a content range of zinc in the at least one zinc-containing portion is (70, 100] wt.% and a microscopic structure of zinc in the zinc-containing portion is at least one of a non-equiaxed structure, an ultrafine-grained structure, or an equiaxed structure with a grain size number of 7 to 14. After the implantable apparatus is implanted in vivo, a zinc corrosion product may be generated, and the concentration of the zinc corrosion product in the surrounding tissue of the zinc-containing portion of the implantable apparatus may inhibit hyperplasia of smooth muscle cells and would not render necrosis of normal tissue cells.
(FR) La présente invention concerne un appareil implantable, comprenant au moins une partie contenant du zinc corrodable, une plage de teneurs en zinc dans l’au moins une partie contenant du zinc étant [30, 50) % en poidset le zinc dans la partie contenant du zinc est une structure amorphe, ou une plage de teneur en zinc dans l’au moins une partie contenant du zinc étant [50, 70] % en poidset une structure microscopique de zinc dans la partie contenant du zinc est au moins l'une d'une structure amorphe, d'une structure non équiaxe, d'une structure à grains ultrafins, ou d’une structure équiaxe ayant un nombre de taille de grain de 7 à 14, ou une plage de teneur en zinc dans l’au moins une partie contenant du zinc étant (70, 100] % en poidset une structure microscopique de zinc dans la partie contenant du zinc est au moins l'une d'une structure non équiaxe, d'une structure à grains ultrafins ou d'une structure équiaxe ayant un nombre de taille de grain de 7 à 14. Après l'implantation de l'appareil implantable in vivo, un produit de corrosion du zinc peut être généré, et la concentration du produit de corrosion du zinc dans le tissu environnant de la partie contenant du zinc de l'appareil implantable peut inhiber l'hyperplasie de cellules de muscle lisse et ne rendrait pas la nécrose de cellules de tissu normales.
(ZH) 植入式器械,具有至少一个可以腐蚀的含锌部,至少一个含锌部中的的锌含量范围为[30,50)wt.%,且含锌部中的锌为非晶态组织或者,至少一个含锌部中的锌含量范围为[50,70]wt.%,且含锌部中的锌的显微组织选自非晶、非等轴晶组织、超细晶组织或者晶粒度范围为7-14级的等轴晶组织中的至少一种,或者,至少一个含锌部中的锌含量范围为(70,100]wt.%,且含锌部中的锌的显微组织选自非等轴晶组织、超细晶组织或者晶粒度范围为7-14级的等轴晶组织中的至少一种。植入式器械在植入体内后,生成锌腐蚀产物,且植入式器械的含锌部的周围组织中的锌腐蚀产物浓度既可抑制平滑肌细胞增生,也不会导致正常组织细胞坏死。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)