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1. (WO2019007380) INORGANIC SALT-CONTAINING LAYERED DISSOLVING MICRO-NEEDLE CONTAINING INORGANIC SALT
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Pub. No.: WO/2019/007380 International Application No.: PCT/CN2018/094582
Publication Date: 10.01.2019 International Filing Date: 05.07.2018
IPC:
A61K 9/00 (2006.01) ,A61K 38/00 (2006.01) ,A61K 47/36 (2006.01) ,A61K 47/30 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
Applicants:
中国科学院理化技术研究所 TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES [CN/CN]; 中国北京市 海淀区中关村东路29号 29 Zhongguancun East Road, Haidian District Beijing 100190, CN
Inventors:
高云华 GAO, Yunhua; CN
杨国忠 YANG, Guozhong; CN
贺美琳 HE, Meilin; CN
赵小峪 ZHAO, Xiaoyu; CN
张锁慧 ZHANG, Suohui; CN
Agent:
北京正理专利代理有限公司 BEIJING JANLEA PATENT AGENCY CO., LTD.; 中国北京市 西城区车公庄大街甲4号物华大厦A座15层1503室 Room1503, 15th Floor, Tower A, Wuhua Mansion A4 Chegongzhuang Avenue Xicheng District Beijing 100044, CN
Priority Data:
201710546759.306.07.2017CN
Title (EN) INORGANIC SALT-CONTAINING LAYERED DISSOLVING MICRO-NEEDLE CONTAINING INORGANIC SALT
(FR) SEL INORGANIQUE CONTENANT DES MICRO-AIGUILLES DE DISSOLUTION EN COUCHE CONTENANT LE SEL INORGANIQUE
(ZH) 一种含有无机盐的分层溶解微针
Abstract:
(EN) An inorganic salt-containing layered dissolving micro-needle containing inorganic salt, and a preparation method therefor. The inorganic salt-containing layered dissolving micro-needle comprises a substrate, a needle body on the substrate, and a needle tip on the needle body. The needle tip is made by mixing an inorganic salt solution, a stabilizer, a film-forming water-soluble polymer material, and a bioactive component; the needle body and the substrate are made of the film-forming water-soluble polymer material, or the film-forming water-soluble polymer material and the stabilizer. The inorganic salt-containing layered dissolving micro-needle containing inorganic salt improves the formability of a needle tip of an inorganic salt-containing micro-needle and improves stability of a bioactive component.
(FR) L'invention concerne un sel inorganique contenant des micro-aiguilles de dissolution en couche contenant le sel inorganique, et son procédé de préparation. Le sel inorganique, contenant des micro-aiguilles de dissolution en couche contenant le sel inorganique, comprend un substrat, un corps d'aiguille sur le substrat, et une pointe d'aiguille sur le corps d'aiguille. La pointe d'aiguille est obtenue par mélange d'une solution de sel inorganique, d'un stabilisant, d'un matériau polymère filmogène soluble dans l'eau et d'un composant bioactif; le corps d'aiguille et le substrat sont constitués du matériau polymère filmogène soluble dans l'eau, ou du matériau polymère filmogène soluble dans l'eau et du stabilisant. Le sel inorganique contenant des micro-aiguilles de dissolution en couche contenant le sel inorganique améliore l'aptitude à former une pointe d'aiguille d'une micro-aiguille contenant le sel inorganique et améliore la stabilité d'un composant bioactif.
(ZH) 一种含有无机盐的分层溶解微针及其制备方法,所述含有无机盐的分层溶解微针包括基底、基底上的针体和针体上的针尖;所述针尖由无机盐溶液、稳定剂、成膜性的水溶性高分子材料和生物活性成分混合制成;所述针体和基底由成膜性的水溶性高分子材料或成膜性的水溶性高分子材料与稳定剂制成,所述含有无机盐的分层溶解微针改善了含无机盐的微针针尖的成形性,提高了生物活性成分的稳定性。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)