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1. (WO2019007072) USE OF Y PEPTIDE IN PREPARATION OF DRUG OR HEALTHCARE PRODUCT FOR LOWERING BLOOD PRESSURE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/007072 International Application No.: PCT/CN2018/076277
Publication Date: 10.01.2019 International Filing Date: 11.02.2018
IPC:
A61K 38/05 (2006.01) ,A61P 9/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
05
Dipeptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
12
Antihypertensives
Applicants:
广州世优生物科技有限公司 WITHYOU BIOTECHNOLOGY CO., LTD. [CN/CN]; 中国广东省广州市 高新技术产业开发区科学城揽月路3号广州国际企业孵化器G区G104房 Room G104, G District of International Business Incubator, No.3, Lanyue Road, Science City, Hi-Tech Industrial Development Zone Guangzhou, Guangdong 510630, CN
Inventors:
潘武广 PAN, Wuguang; CN
朱威 ZHU, Wei; CN
Agent:
广州嘉权专利商标事务所有限公司 JIAQUAN IP LAW FIRM; 中国广东省广州市 天河区黄埔大道西100号富力盈泰广场A栋910张萍 ZHANG, Ping No.910, Building A, Winner Plaza, No.100, West Huangpu Avenue, Tianhe District Guangzhou, Guangdong 510627, CN
Priority Data:
201710550021.407.07.2017CN
Title (EN) USE OF Y PEPTIDE IN PREPARATION OF DRUG OR HEALTHCARE PRODUCT FOR LOWERING BLOOD PRESSURE
(FR) APPLICATION D’UN PEPTIDE Y DANS LA PRÉPARATION D’UN MÉDICAMENT HYPOTENSEUR OU D’UN PRODUIT DE SANTÉ
(ZH) Y肽在制备降血压药物或保健品中的应用
Abstract:
(EN) Disclosed is the use of a dipeptide YY in the preparation of a drug or healthcare product for lowering blood pressure. According to the crystal structure of the enzyme ACE, which structure is already determined, the present invention uses a molecular docking method and uses a self-developed software to carry out virtual screening on the ACE inhibitory effect of the dipeptide, experimentally verifies the ACE inhibitory activity of the dipeptide obtained by means of virtual screening, and finds that the dipeptide YY has a relatively good ACE inhibitory activity. A peptide or protein composed of a plurality of Ys can be hydrolysed to form an active YY peptide in vivo, and hence plays the same or a similar role.
(FR) L’invention concerne l’application d’un peptide Y dans la préparation d’un médicament hypotenseur ou d’un produit de santé. Selon l’invention, un criblage virtuel a été réalisé, moyennant un procédé d'amarrage moléculaire faisant appel à un logiciel autodéveloppé, sur un dipeptide servant d’inhibiteur de l’enzyme de conversion (ECA), après quoi on a procédé à une vérification expérimentale de l'activité inhibitrice de l'ECA par ledit dipeptide criblé virtuellement. On a découvert que l’activité inhibitrice de l’ECA du dipeptide YY s’en trouve améliorée. Le peptide ou la protéine formée d’une pluralité de Y permet d’obtenir par hydrolyse un peptide YY actif in vivo avec des résultats semblables ou analogues.
(ZH) 本发明公开了二肽YY在制备降血压药物或保健品中的应用。本发明根据已经确定的ACE酶晶体结构,采用分子对接法,利用自研软件对二肽的ACE抑制作用进行虚拟筛选,并对虚拟筛选得到的二肽的ACE抑制活性进行实验验证,发现二肽YY具有较好的ACE抑制活性。多个Y组成的肽或蛋白质,在体内可以水解成活性YY肽,从而发挥相同或类似的效果。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)