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1. (WO2019007019) PSORALEN POLYMERNANOPARTICLE PREPARATION AND PREPARATION METHOD THEREFOR
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Pub. No.: WO/2019/007019 International Application No.: PCT/CN2018/072175
Publication Date: 10.01.2019 International Filing Date: 11.01.2018
IPC:
A61K 9/51 (2006.01) ,A61K 31/37 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
51
Nanocapsules
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
365
Lactones
366
having six-membered rings, e.g. delta-lactones
37
Coumarins, e.g. psoralen
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
暨南大学 JINAN UNIVERSITY [CN/CN]; 中国广东省广州市 黄埔大道西601号 601 Huangpu Avenue West Guangzhou, Guangdong 510000, CN
Inventors:
蔡宇 CAI, Yu; CN
李倩文 LI, Qianwen; CN
袁月玲 YUAN, Yueling; CN
张荣华 ZHANG, Ronghua; CN
杨丽 YANG, Li; CN
王冰月 WANG, Bingyue; CN
黄青青 HUANG, Qingqing; CN
Agent:
深圳市精英专利事务所 SHENZHEN TALENT PATENT SERVICE; 中国广东省深圳市 福田区深南中路6009号绿景广场B栋20层B B, 20/F, Building B Lvjing Square, 6009 Shennan Middle Road, Futian District Shenzhen, Guangdong 518000, CN
Priority Data:
201710547252.X06.07.2017CN
Title (EN) PSORALEN POLYMERNANOPARTICLE PREPARATION AND PREPARATION METHOD THEREFOR
(FR) PRÉPARATION DE NANOPARTICULES POLYMÈRES DE PSORALÈNE ET PROCÉDÉ DE PRÉPARATION ASSOCIÉ
(ZH) 一种补骨脂素聚合物纳米粒制剂以及制备方法
Abstract:
(EN) A psoralen polymernanoparticle preparation and a preparation method therefor, relating to the technical field of polymernanoparticle preparations. The psoralen polymernanoparticle preparation with a high encapsulation efficiency is prepared by using a proper amount of psoralen, polylactide-glycolide, soybean phospholipid, and polyethylene glycol 1000 vitamin E succinate as raw materials, and in particular by using polyethylene glycol 1000 vitamin E succinate as a surfactant and soybean phospholipid as a lipid. By optimizing the preparation conditions of the psoralen polymernanoparticle preparation, the encapsulation efficiency of the psoralen polymernanoparticle preparation can be further improved. The encapsulation efficiency is up to 84.97%.
(FR) L'invention concerne une préparation de nanoparticules polymères de psoralène et un procédé de préparation associé, appartenant au domaine technique des préparations de nanoparticules polymères. La préparation de nanoparticules polymères de psoralène à efficacité d'encapsulation élevée est préparée à l'aide d'une quantité appropriée de psoralène, de polylactide-glycolide, de phospholipide de soja, et de succinate de vitamine E et de poly(éthylèneglycol) 1000 en tant que matières premières, et en particulier à l'aide du succinate de vitamine E et de poly(éthylèneglycol) 1000 en tant que tensioactif et d'un phospholipide de soja en tant que lipide. Par optimisation des conditions de préparation de la préparation de nanoparticules polymères de psoralène, l'efficacité d'encapsulation de la préparation de nanoparticules polymères de psoralène peut être davantage améliorée. L'efficacité d'encapsulation peut atteindre 84,97 %.
(ZH) 一种补骨脂素聚合物纳米粒制剂以及制备方法,为聚合物纳米粒制剂技术领域。以适量的补骨脂素、聚丙交酯-乙交酯、大豆磷脂和聚乙二醇1000维生素E琥珀酸酯为原料,尤其是以聚乙二醇1000维生素E琥珀酸酯为表面活性剂,以大豆磷脂为脂质,制备包封率高的补骨脂素聚合物纳米粒制剂。通过优化补骨脂素聚合物纳米粒制剂的制备条件,可进一步提高补骨脂素聚合物纳米粒制剂的包封率,包封率84.97%。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)