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1. (WO2019006955) APPLICATION OF ACID AMIDE DIPEPTIDE FOR PREPARING ANTIHYPERTENSIVE DRUG OR HEALTH CARE PRODUCT
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Pub. No.: WO/2019/006955 International Application No.: PCT/CN2017/111648
Publication Date: 10.01.2019 International Filing Date: 17.11.2017
IPC:
A61K 38/05 (2006.01) ,A61P 9/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
05
Dipeptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
12
Antihypertensives
Applicants:
广州世优生物科技有限公司 WITHYOU BIOTECHNOLOGY CO., LTD. [CN/CN]; 中国广东省广州市 高新技术产业开发区科学城揽月路3号广州国际企业孵化器G区G104房 Room G104, G District of International Business Incubator, No.3, Lanyue Road, Science City, Hi-Tech Industrial Development Zone Guangzhou, Guangdong 510630, CN
Inventors:
潘武广 PAN, Wuguang; CN
朱威 ZHU, Wei; CN
Agent:
广州嘉权专利商标事务所有限公司 JIAQUAN IP LAW FIRM; 中国广东省广州市 黄埔大道西100号富力盈泰广场A栋910张萍 ZHANG, Ping No.910, Building A, Winner Plaza, No.100, West Huangpu Avenue, Tianhe District Guangzhou, Guangdong 510627, CN
Priority Data:
201710550021.407.07.2017CN
Title (EN) APPLICATION OF ACID AMIDE DIPEPTIDE FOR PREPARING ANTIHYPERTENSIVE DRUG OR HEALTH CARE PRODUCT
(FR) APPLICATION D’UN DIPEPTIDE AMIDE BASIQUE DANS LA PRÉPARATION D’UN MÉDICAMENT HYPOTENSEUR OU D’UN PRODUIT DE SANTÉ
(ZH) 酸性、酰胺二肽在制备降血压药物或保健品中的应用
Abstract:
(EN) The invention relates to an application of acid amide dipeptide for preparing antihypertensive drug or health care product. Virtual screening has been performed on a dipeptide based on ACE inhibitory effects according to a previously detected ACE enzyme crystal structure by using a self-developed software and implementing a docking method, and experiments have been conducted to verify the ACE inhibitory activity of the virtually screened dipeptide. It has been discovered that the acid or the sulfur-containing amino acid dipeptide optimizes the ACE inhibitory activity.
(FR) L’invention concerne l’application d’un dipeptide amide basique dans la préparation d’un médicament hypotenseur ou d’un produit de santé. Selon l’invention, un criblage virtuel a été réalisé, moyennant un procédé d'amarrage moléculaire faisant appel à un logiciel autodéveloppé, sur un dipeptide servant d’inhibiteur de l’enzyme de conversion (ECA) compte tenu de la structure cristalline mesurée au préalable, après quoi on a procédé à une vérification expérimentale de l'activité inhibitrice de l'ECA par ledit dipeptide criblé virtuellement. On a découvert que l'activité inhibitrice de l’ECA d’un peptide acide ou contenant un amide d’acide aminé.
(ZH) 一种酸性、酰胺二肽在制备降血压药物或保健品中的应用。根据已经测定的ACE酶晶体结构,采用分子对接法,利用自研软件对二肽的ACE抑制作用进行虚拟筛选,并对虚拟筛选得到的二肽的ACE抑制活性进行实验验证,发现酸性或含酰胺基的氨基酸开头的二肽具有ACE抑制活性。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)