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1. (WO2019006472) TARGETED HETERODIMERIC FC FUSION PROTEINS CONTAINING IL-15/IL-15RA AND ANTIGEN BINDING DOMAINS
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Pub. No.: WO/2019/006472 International Application No.: PCT/US2018/040653
Publication Date: 03.01.2019 International Filing Date: 02.07.2018
IPC:
A61P 35/00 (2006.01) ,C07K 14/54 (2006.01) ,C07K 14/715 (2006.01) ,C07K 16/28 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
54
Interleukins (IL)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
715
for cytokines; for lymphokines; for interferons
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
Applicants:
XENCOR, INC. [US/US]; 111 West Lemon Avenue Monrovia, CA 91016, US
Inventors:
BERNETT, Matthew J.; US
DESJARLAIS, John; US
VARMA, Rajat; US
SCHUBBERT, Suzanne; US
DIAZ, Juan; US
Agent:
NG, Jennifer K.; US
MACDOUGALL, Christina; US
MANN, Jeffry, S.; US
TALUKDER, Gargi; US
ANTCZAK, Andrew; US
Priority Data:
62/527,89830.06.2017US
Title (EN) TARGETED HETERODIMERIC FC FUSION PROTEINS CONTAINING IL-15/IL-15RA AND ANTIGEN BINDING DOMAINS
(FR) PROTÉINES DE FUSION FC HÉTÉRODIMÈRES CIBLÉES CONTENANT IL-15/IL-15RA ET DOMAINES DE LIAISON À L'ANTIGÈNE
Abstract:
(EN) The present invention is directed to a novel targeted heterodimeric Fc fusion proteins comprising an IL-15/IL-15Ra Fc fusion protein and an antigen binding domain Fc fusion proteins. In some instances, the antigen binding domain binds to CD8, NKG2A, or NKG2D.
(FR) La présente invention concerne une nouvelle protéine de fusion Fc hétérodimère ciblée comprenant une protéine de fusion Fc d'IL -15/IL-15Ra et un domaine de liaison à l'antigène Fc de protéines de fusion. Dans certains cas, le domaine de liaison à l'antigène se lie à CD8, NKG2A, ou NKG2D.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)