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1. (WO2019006246) HUMAN MICROBIOTA DERIVED N-ACYL AMIDES FOR THE TREATMENT OF HUMAN DISEASE
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Pub. No.: WO/2019/006246 International Application No.: PCT/US2018/040195
Publication Date: 03.01.2019 International Filing Date: 29.06.2018
IPC:
A61K 31/661 (2006.01) ,A61K 31/685 (2006.01) ,A61K 31/7032 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
661
Phosphorus acids or esters thereof not having P-C bonds, e.g. fosfosal, dichlorvos, malathion
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
683
Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
685
one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7028
Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7032
attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyl-diacylglycerides, lactobionic acid, gangliosides
Applicants:
THE ROCKEFELLER UNIVERSITY [US/US]; 1230 York Avenue New York, NY 10021, US
Inventors:
COHEN, Louis; US
BRADY, Sean; US
Agent:
NGUYEN, Quang, D.; US
FONVILLE, Natalie; US
ARTIS, Ryan; US
ALLEN, Justin; US
CHEN, Ming; US
Priority Data:
62/527,31430.06.2017US
Title (EN) HUMAN MICROBIOTA DERIVED N-ACYL AMIDES FOR THE TREATMENT OF HUMAN DISEASE
(FR) N-ACYL AMIDES DÉRIVÉS DU MICROBIOTE HUMAIN POUR LE TRAITEMENT D'UNE MALADIE HUMAINE
Abstract:
(EN) The present invention provides compositions and methods for the modulation of G protein-coupled receptors (GPCRs). The invention provides a genetically engineered cell, wherein the cell expresses a human microbial N-acyl synthase (hm-NAS) gene. In one embodiment, the hm-NAS gene is N-acyl serinol synthase. The invention provides a probiotic composition, the probiotic composition comprises a genetically engineered cell of the invention. The invention provides a method for modulating a G protein-coupled receptor (GPCR) activity in a subject, the method comprises administering to the subject an effective amount of a composition comprising at least one selected from the group consisting of a genetically engineered cell, an hm-NAS gene, and a N-acyl amide.
(FR) La présente invention concerne des compositions et des méthodes pour la modulation de récepteurs couplés à la protéine G (GPCR). L'invention concerne une cellule génétiquement modifiée, la cellule exprimant un gène de synthase N-acyl microbienne humain (hm-NAS). Selon un mode de réalisation, le gène hm-NAS est la synthase de sérinol N-acyle. L'invention concerne une composition probiotique, la composition probiotique comprend une cellule génétiquement modifiée selon l'invention. L'invention procure une méthode de modulation de l'activité du récepteur couplé à la protéine G (GPCR) chez un sujet, la méthode comprend l'administration au sujet d'une certaine quantité efficace d'une composition comprenant une cellule génétiquement modifiée et/ou un gène hm-NAS et/ou un amide N-acyle.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)