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1. (WO2019006237) THERAPEUTIC HUMAN MAST CELLS, COMPOSITIONS, AND METHODS OF TREATING A TUMOR COMPRISING ADMINISTERING AUTOLOGOUS HUMAN MAST CELLS FROM ADIPOSE TISSUE
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Pub. No.: WO/2019/006237 International Application No.: PCT/US2018/040183
Publication Date: 03.01.2019 International Filing Date: 29.06.2018
IPC:
C12N 5/0787 (2010.01) ,A61K 35/15 ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
0787
Granulocytes, e.g. basophils, eosinophils, neutrophils or mast cells
[IPC code unknown for A61K 35/15]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
UNIVERSITY OF NORTH CAROLINA AT GREENSBORO [US/US]; 1613C Moore Humanities and Research Administration Building 1111 Spring Garden Street Greensboro, NC 27402, US
Inventors:
KEPLEY, Christopher; US
PLOTKIN, Jesse; US
Agent:
KIM, Julia, A.; US
Priority Data:
62/527,56630.06.2017US
Title (EN) THERAPEUTIC HUMAN MAST CELLS, COMPOSITIONS, AND METHODS OF TREATING A TUMOR COMPRISING ADMINISTERING AUTOLOGOUS HUMAN MAST CELLS FROM ADIPOSE TISSUE
(FR) MASTOCYTES HUMAINS THÉRAPEUTIQUES, COMPOSITIONS ET PROCÉDÉS DE TRAITEMENT D'UNE TUMEUR COMPRENANT L'ADMINISTRATION DE MASTOCYTES HUMAINS AUTOLOGUES ISSUS DE TISSU ADIPEUX
Abstract:
(EN) This disclosure is directed to mast cells obtained from adipose derived stem cells and sensitized with immunoglobulin-E targeted to a cancer antigen; compositions comprising mast cells obtained from adipose derived stem cells and sensitized with immunoglobulin-E targeted to a cancer antigen; and methods of treating a tumor in a subject, comprising administering to a subject a therapeutically effective amount of mast cells obtained from adipose derived stem cells, wherein the mast cells are autologous to the subject and sensitized with immunoglobulin-E targeted to a cancer antigen.
(FR) La présente invention concerne des mastocytes obtenus à partir de cellules souches dérivées du tissu adipeux et sensibilisés avec l'immunoglobuline E ciblée vers un antigène du cancer; des compositions comprenant des mastocytes obtenus à partir de cellules souches dérivées du tissu adipeux et sensibilisées avec l'immunoglobuline E ciblée vers un antigène du cancer; et des procédés de traitement d'une tumeur chez un sujet, comprenant l'administration à un sujet d'une quantité thérapeutiquement efficace de mastocytes obtenus à partir de cellules souches dérivées du tissu adipeux, les mastocytes étant autologues pour le sujet et sensibilisés avec l'immunoglobuline E ciblée vers un antigène du cancer.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)