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1. (WO2019006169) SYNTHETIC HEME-CONTAINING MOLECULES AND THEIR USE
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Pub. No.: WO/2019/006169 International Application No.: PCT/US2018/040093
Publication Date: 03.01.2019 International Filing Date: 28.06.2018
IPC:
A61K 38/00 (2006.01) ,A61K 38/41 (2006.01) ,A61K 38/42 (2006.01) ,C07K 7/00 (2006.01) ,C07K 14/00 (2006.01) ,C07K 14/795 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
41
Porphyrin- or corrin-ring-containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
41
Porphyrin- or corrin-ring-containing peptides
42
Haemoglobins; Myoglobins
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
795
Porphyrin- or corrin-ring-containing peptides
Applicants:
ROSE, Jason, J. [US/US]; US (US)
BRAVO, Jesus, Tejero [US/US]; US (US)
ISLAM, Kazi, R. [US/US]; US (US)
GLADWIN, Mark, T. [US/US]; US (US)
YURKO, Raymond, B. [US/US]; US (US)
DEMARTINO, Anthony, W. [US/US]; US
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION [US/US]; 1st Floor Gardner Steel Conference Center 130 Thackeray Avenue Pittsburgh, PA 15260, US (AllExceptUS)
Inventors:
ROSE, Jason, J.; US
BRAVO, Jesus, Tejero; US
ISLAM, Kazi, R.; US
GLADWIN, Mark, T.; US
YURKO, Raymond, B.; US
DEMARTINO, Anthony, W.; US
Agent:
CONNOLLY, Jodi, L.; US
Priority Data:
62/525,90928.06.2017US
Title (EN) SYNTHETIC HEME-CONTAINING MOLECULES AND THEIR USE
(FR) MOLÉCULES SYNTHÉTIQUES CONTENANT UN HÈME ET LEUR UTILISATION
Abstract:
(EN) Synthetic heme-containing molecules are described. The heme-containing molecules include a heme group bound to either two non-contiguous peptides or a single contiguous peptide via cysteine residues. Use of the synthetic heme-containing molecules, such as for the treatment of carboxyhemoglobinemia, cyanide poisoning and hydrogen sulfide (H2S) poisoning, is further described.
(FR) La présente invention concerne des molécules synthétiques contenant un hème. Les molécules contenant un hème comprennent un groupe hème lié à deux peptides non contigus ou à un peptide contigu unique par l’intermédiaire de résidus cystéine. L'invention décrit également l’utilisation des molécules synthétiques contenant un hème, par exemple pour le traitement de la carboxyhémoglobinémie, d’un empoisonnement par le cyanure et d’un empoisonnement par le sulfure d’hydrogène (H2S).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)