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1. (WO2019006153) PROTEOLYTIC CASCADE ENHANCEMENT FOR THE TREATMENT OF DISEASE
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Pub. No.: WO/2019/006153 International Application No.: PCT/US2018/040067
Publication Date: 03.01.2019 International Filing Date: 28.06.2018
IPC:
G01N 33/564 (2006.01) ,A61K 38/10 (2006.01) ,A61K 38/14 (2006.01) ,A61K 39/395 (2006.01) ,A61K 48/00 (2006.01) ,A61P 43/00 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
564
for pre-existing immune complex or autoimmune disease
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
10
Peptides having 12 to 20 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
14
Peptides containing saccharide radicals; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Applicants:
ANTHROBIO [US/US]; 4320 Forest Park Ave., #303 St. Louis, Missouri 63108, US
Inventors:
OLIVO, Paul; US
OLSON, Paul; US
SCHRAMM, Elizabeth; US
Agent:
SHORE, David E.; US
REESE, Brian E.; US
ADATO, Ronen; US
AUGST, Alexander D.; US
BUTEAU, Kristen C.; US
BYCHOWSKI, Meaghan E.; US
HAULBROOK, William R.; US
JARRELL, Brenda Herschbach; US
KLEIN, Daniel A.; US
LI, Bin; US
LI, Xiaodong; US
LYON, Charles E.; US
MEDINA, Rolando; US
MONROE, Margo R.; US
NGUYEN, Suzanne P.; US
PACE, Nicholas J.; US
PYSHER, Paul A.; US
REARICK, John P.; US
SAHR, Robert N.; US
SCHONEWALD, Stephanie L.; US
SHAIKH, Nishat A.; US
SHINALL, Michael A.; US
SMITH, Maria C.; US
SUH, Su Kyung; US
VETTER, Michael L.; US
VRABLIK, Tracy L.; US
Priority Data:
62/527,07330.06.2017US
Title (EN) PROTEOLYTIC CASCADE ENHANCEMENT FOR THE TREATMENT OF DISEASE
(FR) AMÉLIORATION DE LA CASCADE PROTÉOLYTIQUE POUR LE TRAITEMENT D'UNE MALADIE
Abstract:
(EN) In some embodiments, the present invention provides methods and compositions including the use of complement-stabilizing reagents to treat disease. In some embodiments, the stabilization reagent of the present invention is useful in a method of enhancing complement activity, e.g., a method including a step of administering at least one complement-stabilizing reagent to subject in need thereof.
(FR) Dans certains modes de réalisation, la présente invention concerne des méthodes et des compositions comprenant l'utilisation de réactifs de stabilisation du complément pour traiter une maladie. Dans certains modes de réalisation, le réactif de stabilisation de la présente invention est utile dans un procédé d'amélioration de l'activité du complément, par exemple, un procédé comprenant une étape d'administration d'au moins un réactif de stabilisation du complément à un sujet en ayant besoin.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)