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1. (WO2019006128) SEPARATION DEVICES FOR BIOLOGICAL SAMPLES
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Claims

What is claimed is:

1. A device for separating a sample, the device comprising:

a vessel for holding a sample, the sample includes a plurality of cells;

a filter membrane within the vessel and positioned adjacent to an end region of the vessel; and

an auger member within the vessel, the auger member designed to place the plurality of cells into contact with the filter membrane.

2. The device of claim 1 , wherein the vessel includes an open first end region and a second end region positioned substantially opposite the open first end region.

3. The device of claim 2, further comprising a fluid passageway formed along the second end region.

4. The device of any one of claims 1-3, wherein at least a portion of the filter membrane is positioned against a bottom end surface of the vessel.

5. The device of any one of claims 1 -3, wherein the filter membrane is spaced from a bottom end surface of the vessel.

6. The device of any one of claims 1 -5, wherein the auger member includes a central shaft and a helical thread disposed about the central shaft.

7. The device of any one of claims 1 -6, wherein the auger member is designed to rotate within the vessel.

8. The device of any one of claims 1 -7, wherein the auger member includes a central shaft and a compression member disposed at an end region of the central shaft, wherein the filter membrane is coupled to the compression member.

9. A device for separating a sample, the device comprising:

a vessel for holding a biological sample, the biological sample includes a plurality of cells;

a filter membrane disposed within the vessel, the filter membrane having a first end along a bottom wall surface of the vessel and a second end spaced from the bottom wall surface; and

a one-way filter within the vessel and positioned adjacent to the second end of the filter membrane, the one-way filter designed to allow cells within the biological sample to pass therethrough in a first direction and the one-way filter being designed to prevent cells within the sample to pass therethrough in a second direction opposite the first direction.

10. The device of claim 9, wherein the filter membrane is substantially cylindrical.

11. The device of any one of claims 9-10, wherein an opening is formed in the vessel along the bottom wall surface.

12. The device of claim 1 1, wherein at least a portion of the filter membrane extends about the opening.

13. The device of claim 1 1, wherein the filter membrane extends circumferentially about the opening.

14. The device of any one of claims 9-13, wherein the one-way filter includes a one-way baffle or a one-way membrane.

15. The device of any one of claims 9-14, wherein the vessel includes a removable tray region.