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1. (WO2019005948) INHIBITION OF VASCULAR MATRIX METALLOPROTEINASE-9 TO TREAT ISCHEMIC INJURY
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Pub. No.: WO/2019/005948 International Application No.: PCT/US2018/039730
Publication Date: 03.01.2019 International Filing Date: 27.06.2018
IPC:
A61K 38/57 (2006.01) ,A61P 35/00 (2006.01) ,C07K 14/81 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
55
Protease inhibitors
57
from animals; from humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
81
Protease inhibitors
Applicants:
TRANSLATIONAL SCIENCES, INC. [US/US]; 6725 E Rovey Avenue Paradise Valley, Arizona 85253, US
Inventors:
REED, Guy L.; US
Agent:
WARREN, William L.; US
WIGLEY, David E.; US
PAPPAS, Peter G.; US
GRIFFIN, III, Malvern U.; US
KING, Kevin W.; US
CHAN, Christopher J.; US
Priority Data:
62/525,50527.06.2017US
Title (EN) INHIBITION OF VASCULAR MATRIX METALLOPROTEINASE-9 TO TREAT ISCHEMIC INJURY
(FR) INHIBITION DE LA MÉTALLOPROTÉINASE MATRICIELLE 9 VASCULAIRE POUR TRAITER UNE LÉSION ISCHÉMIQUE
Abstract:
(EN) Methods and pharmaceutical compositions for treating ischemic injury are provided. The methods include administering a therapeutically effective amount of a vascular matrix metalloproteinase 9 (MMP-9) inhibitor that reduces ischemic injury in a subject.
(FR) L'invention concerne des méthodes et des compositions pharmaceutiques pour le traitement d'une lésion ischémique. Les méthodes comprennent l'administration d'une quantité thérapeutiquement efficace d'un inhibiteur de métalloprotéinase matricielle 9 (MMP-9) vasculaire qui réduit une lésion ischémique chez un sujet.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)