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1. (WO2019005757) COMPOSITIONS AND METHODS FOR IDENTIFYING AND TREATING RESISTANCE TO CTLA4 ANTAGONISTS IN LEUKEMIA
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Pub. No.: WO/2019/005757 International Application No.: PCT/US2018/039446
Publication Date: 03.01.2019 International Filing Date: 26.06.2018
IPC:
C07K 16/28 (2006.01) ,C12Q 1/6886 (2018.01) ,A61P 35/02 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
[IPC code unknown for C12Q 1/6886]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
02
specific for leukemia
Applicants:
DANA-FARBER CANCER INSTITUTE, INC. [US/US]; 450 Brookline Avenue Office of General Counsel 10BP-372A Boston, Massachusetts 02215, US
Inventors:
BACHIREDDY, Pavan; US
Agent:
CLARKE, Daniel W.; US
CHACLAS, George N.; US
COHEN, Jerry; US
COWLES, Christopher R.; US
EMMONS, Richard B.; US
FOLEY, Shawn P.; US
GOLDMAN, Gabriel; US
GOMES, David W.; US
HASAN, Shahid; US
JOBSE, Bruce D.; US
LOPEZ, Orlando; US
MARAIA, Joseph M.; US
MCGRATH, Daniel; US
MILLS, Steven M.; US
MOORE, Ronda P.; US
QUINN, Joseph P.; US
SCHEPPER, Marlo M.; US
SERIO, John C.; US
SORKIN, Paul D.; US
SUSAN, Janine M.; US
Priority Data:
62/525,40127.06.2017US
Title (EN) COMPOSITIONS AND METHODS FOR IDENTIFYING AND TREATING RESISTANCE TO CTLA4 ANTAGONISTS IN LEUKEMIA
(FR) COMPOSITIONS ET PROCÉDÉS D'IDENTIFICATION ET DE TRAITEMENT DE LA RÉSISTANCE À DES ANTAGONISTES CTLA4 DANS LA LEUCÉMIE
Abstract:
(EN) The present invention relates to compositions and methods for identifying and treating resistance to CTLA4 antagonists in neoplasia. In particular, the invention relates to compositions and methods for use in identifying and treating Ipilimumab resistant forms of leukemia.
(FR) La présente invention concerne des compositions et des procédés permettant d'identifier et de traiter la résistance à des antagonistes CTLA4 dans un néoplasme. En particulier, l'invention concerne des compositions et des procédés destinés à être utilisés pour identifier et traiter des formes de leucémie résistant à l'ipilimumab.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)