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1. (WO2019005737) AUTOLOGOUS STEM CELL THERAPIES FOR TREATMENT OF EYE DISEASE
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Pub. No.: WO/2019/005737 International Application No.: PCT/US2018/039413
Publication Date: 03.01.2019 International Filing Date: 26.06.2018
IPC:
C12N 5/0775 (2010.01) ,G01N 33/53 (2006.01) ,A61H 39/00 (2006.01) ,A61H 39/08 (2006.01) ,A61N 1/36 (2006.01) ,A61K 35/28 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
077
Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
0775
Mesenchymal stem cells; Adipose-tissue derived stem cells
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
H
PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
39
Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
H
PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
39
Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
08
Devices for applying needles to such points, i.e. for acupuncture
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
N
ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
1
Electrotherapy; Circuits therefor
18
Applying electric currents by contact electrodes
32
alternating or intermittent currents
36
for stimulation, e.g. heart pace-makers
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
28
Marrow; Spleen
Applicants:
AMD-OPTI, LLC [US/US]; 15755 Ocean Breeze Lane Wellington, FL 33414, US
Inventors:
GRANT, Maria, Bartolomeo; US
Agent:
HSI, Jeffrey, D.; US
DIPIETRANTONIO, Heather, D.; US
Priority Data:
62/524,85126.06.2017US
Title (EN) AUTOLOGOUS STEM CELL THERAPIES FOR TREATMENT OF EYE DISEASE
(FR) THÉRAPIES PAR DES CELLULES SOUCHES AUTOLOGUES POUR LE TRAITEMENT D'UNE MALADIE OCULAIRE
Abstract:
(EN) Provided herein, in some embodiments, are methods that include electro stimulating at least one acupoint in a subject, isolating from a blood sample obtained from the subject cells that are immunocytochemically positive for CD 146 (CD146+), and administering to the subject a pharmaceutical composition of cells comprising non-cultured CD146+ stem cells. Also provided herein are pharmaceutical composition and kits comprising the non-cultured CD146+ stem cells.
(FR) Dans certains modes de réalisation, l'invention concerne des procédés qui comprennent l'électrostimulation d'au moins un point d'acupuncture chez un sujet, l'isolement à partir d'un échantillon de sang obtenu auprès du sujet de cellules qui sont positives au plan immunocytochimique pour CD 146 (CD146 +), et l'administration au sujet d'une composition pharmaceutique de cellules comprenant des cellules souches CD146 + non cultivées. La présente invention concerne également des compositions pharmaceutiques ainsi que des kits comprenant les cellules souches CD146 + non cultivées.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)