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1. (WO2019005642) METHODS OF MAKING AND USING GUIDANCE AND NAVIGATION CONTROL PROTEINS
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Pub. No.: WO/2019/005642 International Application No.: PCT/US2018/039161
Publication Date: 03.01.2019 International Filing Date: 22.06.2018
IPC:
A61K 35/12 (2015.01) ,A61K 35/14 (2015.01) ,A61K 39/00 (2006.01) ,A61K 39/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
14
Blood
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
Applicants:
SYSTIMMUNE, INC. [US/US]; 15318 NE 95th St Redmond, Washington 98052, US
SICHUAN BAILI PHARMACEUTICAL CO. LTD. [CN/CN]; 161 Baili Road, Wenjiang District Chengdu, Sichuan, CN
Inventors:
ZHU, Yi; CN
OLSEN, Ole; US
KHALILI, Jahan; US
XIA, Dong; US
JELLYMAN, David; US
BYKOVA, Katrina; US
ROUSSEAU, Anne-Marie; US
WANG, Camilla; US
GAO, Zeren; US
Agent:
HAN, Zhihua; US
Priority Data:
62/524,55325.06.2017US
62/524,55425.06.2017US
62/524,55725.06.2017US
62/524,55825.06.2017US
62/545,60315.08.2017US
62/551,03228.08.2017US
62/551,03528.08.2017US
62/551,06528.08.2017US
62/648,88027.03.2018US
62/648,88827.03.2018US
Title (EN) METHODS OF MAKING AND USING GUIDANCE AND NAVIGATION CONTROL PROTEINS
(FR) PROCÉDÉS DE PRODUCTION ET D'UTILISATION DE PROTÉINES DE CONTRÔLE DE GUIDAGE ET DE NAVIGATION
Abstract:
(EN) The application provides method of treating a subject having a cancer using a guidance and navigation control (GNC) protein. In one embodiment, the method includes the steps of providing a blood from the subject, isolating peripheral blood mononuclear cells (PBMC) from the blood, isolating a cytotoxic cell from the PBMC, combining a GNC protein with the cytotoxic cell to provide a therapeutic cell, optionally expanding the therapeutic cell to provide an expanded cell population, and administering the therapeutic cell or the expanded cell population to the subject. In one embodiment, the GNC protein may be a bi-specific, tri-specific, or tetra-specific antibody.
(FR) L'invention concerne un procédé de traitement d'un sujet atteint d'un cancer à l'aide d'une protéine de commande de guidage et de navigation (CGN). Dans un mode de réalisation, le procédé comprend les étapes consistant à obtenir du sang auprès du sujet, à isoler des cellules mononucléées du sang périphérique (CMSP) du sang, à isoler une cellule cytotoxique des CMSP, à combiner une protéine CNG avec la cellule cytotoxique pour obtenir une cellule thérapeutique, facultativement à multiplier la cellule thérapeutique pour obtenir une population de cellules multipliées, et à administrer la cellule thérapeutique ou la population de cellules multipliées au sujet. Dans un mode de réalisation, la protéine CGN peut être un anticorps bispécifique, trispécifique ou tétraspécifique.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)