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1. (WO2019005635) ANTI-PD-1 ANTIBODIES AND METHODS OF MAKING AND USING THEREOF

Pub. No.:    WO/2019/005635    International Application No.:    PCT/US2018/039147
Publication Date: Fri Jan 04 00:59:59 CET 2019 International Filing Date: Sat Jun 23 01:59:59 CEST 2018
IPC: C12Q 1/68
Applicants: SYSTIMMUNE, INC.
SICHUAN BAILI PHARMACEUTICAL CO. LTD.
Inventors: KOVACEVICH, Brian
XIA, Dong
JANSEN, Anne
FALLEN, Jon
RENSHAW, Blair
ADAMO, Jeffrey B.
TAN, Phil
GAO, Zeren
ZHU, Yi
Title: ANTI-PD-1 ANTIBODIES AND METHODS OF MAKING AND USING THEREOF
Abstract:
The application provides anti-PD-1 monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.