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1. (WO2019005587) 3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR
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Pub. No.: WO/2019/005587 International Application No.: PCT/US2018/038888
Publication Date: 03.01.2019 International Filing Date: 22.06.2018
IPC:
A61K 31/4155 (2006.01) ,C07D 231/10 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
4155
not condensed and containing further heterocyclic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
231
Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
02
not condensed with other rings
10
having two or three double bonds between ring members or between ring members and non-ring members
Applicants:
ACTON, John, J., III [US/US]; US (NZ, US)
BAO, Jianming [US/CN]; CN (NZ, US)
DENG, Qiaolin [US/US]; US (NZ, US)
EGBERTSON, Melissa [US/US]; US (NZ, US)
FERGUSON, Ronald, III [US/US]; US (NZ, US)
GAO, Xiaolei [US/US]; US (NZ, US)
HARRISON, Scott Timothy [US/US]; US (NZ, US)
KNOWLES, Sandra, L. [US/US]; US (NZ, US)
LI, Chunsing [CN/CN]; CN (NZ, US)
LO, Michael Man-Chu [US/US]; US (NZ, US)
MAZZOLA, Robert, D., Jr. [US/US]; US (NZ, US)
MENG, Zhaoyang [CN/US]; US (NZ, US)
NA, Meng [CN/CN]; CN (NZ, US)
RUDD, Michael, T. [US/US]; US (NZ, US)
SELYUTIN, Oleg, B. [US/US]; US (NZ, US)
TELLERS, David, M. [US/US]; US (NZ, US)
TONG, Ling [US/US]; US (NZ, US)
ZHANG, Fengqi [US/US]; US (NZ, US)
MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907, US (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JO, JP, KE, KG, KH, KM, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
MSD R&D (CHINA) CO., LTD. [CN/CN]; 19-21/F Park Place 1601 Nanjing Road (West) Jing'an District Shanghai 200040, CN (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JO, JP, KE, KG, KH, KM, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
Inventors:
ACTON, John, J., III; US
BAO, Jianming; CN
DENG, Qiaolin; US
EGBERTSON, Melissa; US
FERGUSON, Ronald, III; US
GAO, Xiaolei; US
HARRISON, Scott Timothy; US
KNOWLES, Sandra, L.; US
LI, Chunsing; CN
LO, Michael Man-Chu; US
MAZZOLA, Robert, D., Jr.; US
MENG, Zhaoyang; US
NA, Meng; CN
RUDD, Michael, T.; US
SELYUTIN, Oleg, B.; US
TELLERS, David, M.; US
TONG, Ling; US
ZHANG, Fengqi; US
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907, US
Priority Data:
PCT/CN2017/09038427.06.2017CN
Title (EN) 3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR
(FR) MODULATEURS ALLOSTÉRIQUES DE TYPE 3-(1H-PYRAZOL-4-YL)PYRIDINE DU RÉCEPTEUR MUSCARINIQUE M4 D'ACÉTYLCHOLINE
Abstract:
(EN) The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
(FR) L'invention concerne des composés de pyrazol-4-yl-pyridine qui sont des modulateurs allostériques du récepteur muscarinique M4 d'acétylcholine. La présente invention concerne également des utilisations des composés de l'invention dans le traitement ou la prévention, potentiel, de troubles et maladies neurologiques et psychiatriques dans lesquels les récepteurs muscariniques M4 de l'acétylcholine sont impliqués. La présente invention concerne également des compositions comprenant ces composés. La présente invention concerne aussi des utilisations desdites compositions dans la prévention ou le traitement,,potentiel, de maladies dans lesquelles les récepteurs muscariniques M4 de l'acétylcholine sont impliqués.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)