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1. (WO2019005563) METHODS RELATED TO ACTIVATION OF THE BONE MORPHOGENIC PROTEIN SIGNALING PATHWAY
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Pub. No.: WO/2019/005563 International Application No.: PCT/US2018/038600
Publication Date: 03.01.2019 International Filing Date: 20.06.2018
IPC:
A61K 39/395 (2006.01) ,C07K 16/24 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
24
against cytokines, lymphokines or interferons
Applicants:
ST. JUDE CHILDREN'S RESEARCH HOSPITAL [US/US]; 262 Danny Thomas Place Memphis, TN 38105, US
Inventors:
GUY, Kiplin, R.; US
MIN, Jaeki; US
ROUSSEL, Martine, F.; US
Agent:
SHORTELL, Brian, D.; US
MARTY, Scott, D.; US
KATZ, Mitchell, A.; US
MEADOWS, Brian, C.; US
HATHCOCK, Kevin, W.; US
Priority Data:
62/525,59827.06.2017US
Title (EN) METHODS RELATED TO ACTIVATION OF THE BONE MORPHOGENIC PROTEIN SIGNALING PATHWAY
(FR) MÉTHODES LIÉES À L'ACTIVATION DE LA VOIE DE SIGNALISATION DES PROTÉINES MORPHOGÉNÉTIQUES OSSEUSES
Abstract:
(EN) In one aspect, compounds and compositions that activate BMP signaling and methods of making and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with diminished BMP signaling such as, for example, cancer, juvenile polyposis syndrome, hereditary pulmonary arterial hypertension, obesity osteosporosis, and chronic kidney disease. The disclosed compounds and compositions can also be useful in cartilage repair and bone formation. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
(FR) La présente invention concerne, selon un aspect, des composés et des compositions qui modulent la signalisation dépendante des BMP, ainsi que des procédés de fabrication et des méthodes d'utilisation de ceux-ci. Les composés et compositions de l'invention peuvent être utiles pour des troubles associés à une diminution de la signalisation dépendante des BMP, tels que, par exemple, le cancer, le syndrome de polypose juvénile, l'hypertension artérielle pulmonaire héréditaire, l'ostéoporose liée à l'obésité, et la maladie rénale chronique. Les composés et compositions de l'invention peuvent aussi être utiles dans la réparation du cartilage et la formation osseuse. Le présent abrégé est proposé à titre d'outil d'exploration pour permettre les recherches sur cette technique particulière et n'est pas destiné à limiter la présente invention.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)