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1. (WO2019004811) CHIMERIC PROTEIN FOR THE PREVENTION AND DIAGNOSIS OF PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME (PRRS)
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Pub. No.: WO/2019/004811 International Application No.: PCT/MX2018/000052
Publication Date: 03.01.2019 International Filing Date: 13.06.2018
IPC:
C07K 14/08 (2006.01) ,A61K 39/12 (2006.01) ,C12N 7/04 (2006.01) ,G01N 33/569 (2006.01) ,A61P 31/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7
Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
04
Inactivation or attenuation; Producing viral sub-units
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
569
for micro-organisms, e.g. protozoa, bacteria, viruses
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
Applicants:
CENTRO DE INVESTIGACIÓN Y ASISTENCIA EN TECNOLOGÍA Y DISEÑO DEL ESTADO DE JALISCO A.C. [MX/MX]; Av. Normalistas 800, Colinas de la Normal Guadalajara, Jalisco, 44270, MX
Inventors:
GUTIÉRREZ ORTEGA, Abel; MX
CAMACHO VILLEGAS, Tanya Amanda; MX
HERNÁNDEZ GUTIÉRREZ, Rodolfo; MX
MARTÍNEZ VELÁZQUEZ, Moisés; MX
MANUEL CABRERA, Carlos Alberto; MX
GAONA BERNAL, Jorge; MX
Agent:
AGUILAR NAVARRO, Carlos Omar; MX
ALZAGA SÁNCHEZ, Citlalli Haidé; MX
Priority Data:
MX/a/2017/00875129.06.2017MX
Title (EN) CHIMERIC PROTEIN FOR THE PREVENTION AND DIAGNOSIS OF PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME (PRRS)
(FR) PROTÉINE CHIMÉRIQUE PERMETTANT DE PRÉVENIR ET DE DIAGNOSTIQUER UN SYNDROME DYSGÉNÉSIQUE ET RESPIRATOIRE DU PORC (SDRP)
(ES) PROTEÍNA QUIMÉRICA PARA LA PREVENCIÓN Y EL DIAGNÓSTICO DEL SÍNDROME RESPIRATORIO Y REPRODUCTIVO PORCINO (PRSS)
Abstract:
(EN) The present invention relates to a chimeric protein comprising short sequences from some of the structural proteins in porcine respiratory and reproductive syndrome virus (PRRSV). The protein is used as capture antigen in an enzyme-linked immunoadsorption assay for the detection of antibodies present in sera from pigs infected with the virus. The protein is also administered to piglets and induces a rapid antibody response, thereby acting as an immunising agent for the control of PRRSV in the early stages of pig growth.
(FR) La présente invention concerne une protéine chimérique composée de séquences courtes de certaines des protéines structurelles du virus du syndrome dysgénésique et respiratoire du porc (SDRP). Ladite protéine est utilisée comme antigène de capture dans le cadre d'un dosage par immunoadsorption lié à des enzymes permettant la détection d'anticorps présents dans des sérums de porcs infectés par le virus. La protéine est également administrée à des cochons de lait et induit une réponse rapide d'anticorps, agissant ainsi comme un agent d'immunisation qui permet de contrôler le SDRP à des étapes précoces de la croissance du porc.
(ES) La presente invención se refiere a una proteína quimérica conformada por secuencias cortas de algunas de algunas de las proteínas estructurales del virus del síndrome respiratorio y reproductivo porcino (PRRSV). La proteína es utilizada como antígeno de captura en un ensayo por inmunoadsorción ligado a enzimas para la detección de anticuerpos presentes en sueros de cerdos infectados con el virus. La proteína también es administrada en lechones e induce una respuesta rápida de anticuerpos, actuando como agente inmunizante para el control del PRRSV en etapas tempranas del crecimiento del cerdo.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)