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1. (WO2019004668) NANOVESICLE DERIVED FROM PROTEUS GENUS BACTERIA, AND USE THEREOF
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Pub. No.: WO/2019/004668 International Application No.: PCT/KR2018/007144
Publication Date: 03.01.2019 International Filing Date: 25.06.2018
IPC:
C12Q 1/689 (2018.01) ,C12Q 1/6851 (2018.01) ,A61K 8/99 (2006.01) ,A61K 35/74 (2006.01) ,A23L 33/135 (2016.01)
[IPC code unknown for C12Q 1/689][IPC code unknown for C12Q 1/6851]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8
Cosmetics or similar toilet preparations
18
characterised by the composition
96
containing materials, or derivatives thereof, of undetermined constitution
99
from micro-organisms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
66
Materials from micro-organisms
74
Bacteria
[IPC code unknown for A23L 33/135]
Applicants:
주식회사 엠디헬스케어 MD HEALTHCARE INC. [KR/KR]; 서울시 마포구 월드컵북로56길 9, 1303호 (상암동, 우리기술빌딩) (Sangam-dong,Woori Technology Bldg.) #1303, 9, World Cup buk-ro 56-gil, Mapo-gu, Seoul 03923, KR
Inventors:
김윤근 KIM, Yoon-Keun; KR
Agent:
이명진 LEE, Myoung-Jin; KR
Priority Data:
10-2017-008304730.06.2017KR
10-2018-007230722.06.2018KR
Title (EN) NANOVESICLE DERIVED FROM PROTEUS GENUS BACTERIA, AND USE THEREOF
(FR) NANOVÉSICULE DÉRIVÉE DE BACTÉRIES DU GENRE PROTEUS ET SON UTILISATION
(KO) 프로테우스 속 세균 유래 나노소포 및 이의 용도
Abstract:
(EN) The present invention relates to a vesicle derived from Proteus genus bacteria, and a use thereof. The inventors experimentally confirmed that, compared to normal people, the vesicle is significantly reduced in samples from cancer patients suffering from stomach cancer, colorectal cancer, liver cancer, biliary duct cancer, pancreatic cancer, lung cancer, breast cancer, or ovarian cancer and the like, and patients with allergic respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), or atopic dermatitis and the like, cardiovascular diseases such as myocardial infarction, cardiomyopathy, variant angina pectoris, or atrial fibrillation and the like, metabolic diseases such as diabetes and the like and neuropsychiatric diseases such as Parkinson's disease or depression and the like, and the vesicle inhibits the secretion of inflammatory mediators by pathogenic vesicles, while also exhibiting an anticancer effect. It is anticipated that the vesicle derived from Proteus genus bacteria can be usefully utilized to develop diagnostic methods and compositions for preventing, treating, and/or improving cancer, cardiovascular diseases, metabolic diseases, neuropsychiatric diseases, allergic respiratory diseases, and inflammatory intestinal diseases.
(FR) La présente invention concerne une vésicule dérivée de bactéries du genre Proteus et son utilisation. Les inventeurs ont confirmé expérimentalement que, comparativement à des personnes saines, la vésicule est significativement réduite dans des échantillons provenant de patients cancéreux souffrant du cancer de l'estomac, du cancer colorectal, du cancer du foie, du cancer du conduit biliaire, du cancer du pancréas, du cancer du poumon, du cancer du sein ou du cancer de l'ovaire et autres, et de patients présentant des maladies respiratoires allergiques telles que l'asthme, la bronchopneumopathie chronique obstructive (BPCO), ou la dermatite atopique et autres, des maladies cardiovasculaires telles que l'infarctus du myocarde, la cardiomyopathie, une variante de l'angine de poitrine, ou la fibrillation auriculaire et autres, des maladies métaboliques telles que le diabète et autres et des maladies neuropsychiatriques telles que la maladie de Parkinson ou la dépression et autres, et que la vésicule inhibe la sécrétion des médiateurs inflammatoires par des vésicules pathogènes, tout en manifestant également un effet anticancéreux. La vésicule dérivée de bactéries du genre Proteus devrait pouvoir être utilement utilisée pour développer des méthodes et des compositions diagnostiques pour prévenir, traiter, et/ou améliorer le cancer, les maladies cardiovasculaires, les maladies métaboliques, les maladies neuropsychiatriques, les maladies respiratoires allergiques et les maladies intestinales inflammatoires.
(KO) 본 발명은 프로테우스 속 세균 유래 소포 및 이의 용도에 관한 것이다. 본 발명자들은 정상인에 비하여 위암, 대장암, 간암, 담도암, 췌장암, 폐암, 유방암, 난소암 등의 암환자, 천식, 만성폐쇄성폐질환(COPD), 아토피피부염 등의 알레르기-호흡기 질환, 심근경색, 심근병증, 이형협심증, 심방세동 등의 심혈관질환, 당뇨병 등의 대사질환, 및 파킨슨병, 우울증 등의 신경-정신질환 환자의 샘플에 상기 소포가 유의하게 감소 되어 있고, 상기 소포는 병원성 소포에 의한 염증매개체 분비를 억제함과 동시에 항암효능을 보임을 실험적으로 확인하였는바, 본 발명에 따른 프로테우스 속 세균 유래 소포는 암, 심혈관질환, 대사질환, 및 신경-정신질환, 알레르기-호흡기질환 및 염증성 장질환의 진단방법, 및 예방, 치료 및/또는 개선용 조성물을 개발하기 위한 목적으로 유용하게 이용될 수 있을 것으로 기대된다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)