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1. (WO2019004533) METHOD FOR DIRECTLY REPROGRAMMING CELLS IN URINE INTO KERATINOCYTE STEM CELLS AND METHOD FOR PREPARING COMPOSITION FOR PROMOTING SKIN REGENERATION BY USING REPROGRAMMED KERATINOCYTE STEM CELLS
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Pub. No.: WO/2019/004533 International Application No.: PCT/KR2017/014648
Publication Date: 03.01.2019 International Filing Date: 13.12.2017
IPC:
C12N 5/071 (2010.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
Applicants:
주식회사 스템랩 STEMLAB INC. [KR/KR]; 서울시 성북구 안암로 145, 고려대학교 산학관 711호 #711, Techno Complex of Korea University, 145, Anam-ro Seongbuk-gu Seoul 02841, KR
Inventors:
전은경 JUN, Eun Kyoung; KR
정걸 ZHENG, Jie; KR
강필준 KANG, Phil Jun; KR
손다련 SON, Da-Ryeon; KR
장지훈 JANG, Ji-Hoon; KR
홍원준 HONG, Won Jun; KR
박정현 PARK, Jung-Hyun; KR
박규만 PARK, Gyu Man; KR
김인용 KIM, In Yong; KR
Agent:
특허법인 다나 DANA PATENT LAW FIRM; 서울시 강남구 역삼로 3길 11, 광성빌딩 신관 4~6층 4~6th Floor, New Wing, Gwangsung Bldg., 11 Yeoksam-ro 3-gil Gangnam-gu Seoul 06242, KR
Priority Data:
10-2017-008353530.06.2017KR
Title (EN) METHOD FOR DIRECTLY REPROGRAMMING CELLS IN URINE INTO KERATINOCYTE STEM CELLS AND METHOD FOR PREPARING COMPOSITION FOR PROMOTING SKIN REGENERATION BY USING REPROGRAMMED KERATINOCYTE STEM CELLS
(FR) PROCÉDÉ DE REPROGRAMMATION DIRECTE DE CELLULES DANS L'URINE EN CELLULES SOUCHES KÉRATINOCYTAIRES ET PROCÉDÉ DE PRÉPARATION DE COMPOSITION POUR FAVORISER LA RÉGÉNÉRATION CUTANÉE À L'AIDE DE CELLULES SOUCHES KÉRATINOCYTAIRES REPROGRAMMÉES
(KO) 소변세포로부터 케라티노사이트 줄기세포로의 직접 역분화 방법 및 역분화된 케라티노사이트 줄기세포를 이용한 피부재생 촉진용 조성물의 제조방법
Abstract:
(EN) The present invention relates to: a method for inducing the reprogramming of cells in urine into keratinocyte stem cells by introducing reprogramming factors Bmi1 and dNP63a; and a composition for promoting skin regeneration, containing a keratinocyte stem cell-conditioned medium as an active ingredient, wherein the keratinocyte stem cell was obtained through induced reprogramming.
(FR) La présente invention concerne : un procédé pour induire la reprogrammation de cellules dans l'urine en cellules souches kératinocytaires par l'introduction des facteurs de reprogrammation Bmi1 et dNP63a ; et une composition pour favoriser la régénération cutanée, contenant un milieu conditionné de cellules souches kératinocytaires en tant que principe actif, la cellule souche kératinocytaire étant obtenue par reprogrammation induite.
(KO) 본 발명은 역분화 인자 Bmi1 및 dNP63a를 도입하여 소변세포로부터 케라티노사이트 줄기세포의 역분화 유도 방법 및 유도된 역분화 케라티노사이트 줄기세포 컨디션드 배지를 유효성분으로 하는 피부 재생 촉진용 조성물에 관한 것이다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)