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1. (WO2019004492) COMPOSITION FOR PREVENTING OR TREATING OBESITY OR LIPID-RELATED METABOLIC DISEASES CONTAINING ACRYLAMIDE-BASED COMPOUNDS AS ACTIVE INGREDIENTS
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Pub. No.: WO/2019/004492 International Application No.: PCT/KR2017/006732
Publication Date: 03.01.2019 International Filing Date: 26.06.2017
IPC:
A61K 31/36 (2006.01) ,A23L 33/10 (2016.01) ,A61K 8/49 (2006.01) ,A23K 20/121 (2016.01) ,A61Q 19/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
357
having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
36
Compounds containing methylenedioxyphenyl groups, e.g. sesamin
[IPC code unknown for A23L 33/10]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8
Cosmetics or similar toilet preparations
18
characterised by the composition
30
containing organic compounds
49
containing heterocyclic compounds
[IPC code unknown for A23K 20/121]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
Q
SPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19
Preparations for care of the skin
Applicants:
한국식품연구원 KOREA FOOD RESEARCH INSTITUTE [KR/KR]; 경기도 성남시 분당구 안양판교로1201번길 62 62, Anyangpangyo-ro 1201beon-gil Bundang-gu, Seongnam-si Gyeonggi-do 13539, KR
Inventors:
최상윤 CHOI, Sangyoon; KR
김상희 KIM, Sanghee; KR
최인욱 CHOI, Inwook; KR
Agent:
특허법인(유)화우 YOON & YANG (IP) LLC; 서울시 강남구 테헤란로108길 11, 4층 4th Fl., 11, Teheran-ro 108-gil Gangnam-gu Seoul 06175, KR
Priority Data:
Title (EN) COMPOSITION FOR PREVENTING OR TREATING OBESITY OR LIPID-RELATED METABOLIC DISEASES CONTAINING ACRYLAMIDE-BASED COMPOUNDS AS ACTIVE INGREDIENTS
(FR) COMPOSITION DE PRÉVENTION OU DE TRAITEMENT DE L’OBÉSITÉ OU DE MALADIES MÉTABOLIQUES LIÉES AUX LIPIDES CONTENANT DES COMPOSÉS À BASE D’ACRYLAMIDE COMME PRINCIPES ACTIFS
(KO) 아크릴아미드계 화합물을 유효성분으로 함유하는 비만 또는 지질관련 대사성 질환의 예방 또는 치료용 조성물
Abstract:
(EN) The present invention relates to use of acrylamide-based compounds and derivatives thereof for the prevention or treatment/improvement of obesity or lipid-related metabolic diseases. Since the acrylamide-based compounds of the present invention inhibited adipocyte differentiation without cytotoxicity, inhibited the expression of FAS, a factor associated with obesity and lipid metabolism, inhibited the activity and expression of PPAR-γ, and reduced feed intake and body weight gain, fat cell size, and blood triglyceride content without exhibiting liver toxicity in vivo, the compounds have an excellent anti-obesity effect and lipid metabolism improving effect. Therefore, the compounds of the present invention are very useful as these compounds can be used in various industrial fields such as in medicines, health functional foods, cosmetics, feed additives, and the like as a material capable of preventing, treating, and improving obesity or lipid-related metabolic diseases.
(FR) La présente invention concerne l’utilisation de composés à base d’acrylamide et leurs dérivés pour la prévention ou le traitement/l’atténuation de l’obésité ou de maladies métaboliques liées aux lipides. Dans la mesure où les composés à base d’acrylamide selon la présente invention inhibent la différenciation des adipocytes sans cytotoxicité, inhibent l’expression de CAS, un facteur associé à l’obésité et au métabolisme des lipides, inhibent l’activité et l’expression de PPAR-γ, et réduisent la prise alimentaire, la prise de poids corporel, la taille des adipocytes et la teneur en triglycéride dans le sang, sans présenter de toxicité hépatique in vivo, les composés possèdent d'excellents effets anti-obésité et d’amélioration du métabolisme des lipides. Par conséquent, les composés selon la présente invention sont très utiles dans la mesure où ils peuvent être utilisés dans divers domaines industriels tels que les médicaments, les alicaments, les cosmétiques, les additifs alimentaires, et similaires, comme matériaux susceptibles de prévenir, de traiter et d'atténuer l’obésité ou les maladies métaboliques liées aux lipides.
(KO) 본 발명은 아크릴아미드계 화합물 및 이의 유도체들의 비만 또는 지질관련 대사성 질환의 예방 또는 치료/개선용 용도에 관한 것이다. 본 발명의 아크릴아미드계 화합물은 세포 독성 없이 지방세포분화를 억제하고 비만 및 지질 대사 관련 인자인 FAS의 발현을 억제하며, PPAR-γ의 활성 및 발현을 억제하였고, 인 비보(in vivo) 상에서도 간 독성을 나타내지 않으면서 사료섭취량 및 체중증가량, 지방세포크기, 및 혈중 중성지방 함량을 감소시키는바 우수한 항비만 효과 및 지질 대사 개선 효과를 가진다. 따라서 본 발명의 화합물은 비만 또는 지질 관련 대사성 질환을 예방, 치료 및 개선할 수 있는 소재로서 의약품, 건강기능식품, 화장료, 사료 첨가제 등 다양한 산업 분야에 사용될 수 있어 매우 유용하다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)