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1. (WO2019003224) BIOCOMPATIBLE NANOFIBER ADHESIVE
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Pub. No.: WO/2019/003224 International Application No.: PCT/IL2018/050702
Publication Date: 03.01.2019 International Filing Date: 26.06.2018
IPC:
A61L 15/32 (2006.01) ,A61L 15/38 (2006.01) ,A61L 15/42 (2006.01) ,D01D 5/04 (2006.01) ,D01F 8/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
15
Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
16
Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
22
containing macromolecular materials
32
Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
15
Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
16
Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
38
containing enzymes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
15
Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
16
Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
42
Use of materials characterised by their function or physical properties
D TEXTILES; PAPER
01
NATURAL OR ARTIFICIAL THREADS OR FIBRES; SPINNING
D
MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES, OR RIBBONS
5
Formation of filaments, threads, or the like
04
Dry spinning methods
D TEXTILES; PAPER
01
NATURAL OR ARTIFICIAL THREADS OR FIBRES; SPINNING
F
CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES, OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
8
Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
02
from cellulose, cellulose derivatives, or proteins
Applicants:
SHEETRIT, Eyal [IL/IL]; IL
Inventors:
SHEETRIT, Eyal; IL
Agent:
ENTIS, Allan C.; A.C. ENTIS-IP LTD. 6 Raoul Wallenberg 69719 Tel Aviv, IL
ENTIS, Allan C.; IL
Priority Data:
62/524,64726.06.2017US
Title (EN) BIOCOMPATIBLE NANOFIBER ADHESIVE
(FR) ADHÉSIF DE NANOFIBRES BIOCOMPATIBLES
Abstract:
(EN) A nanofiber comprising a cross-linkable protein polymer and a transglutaminase. A method for producing a nanofiber, the method comprising: combining a first solution comprising a cross- linkable protein polymer and a second solution comprising a transglutaminase to produce a liquid electro spinning mixture (LEM) characterized by an environment that is unsuitable for the transglutaminase to be enzymatically active on the cross-linkable protein polymer; and electro spinning the LEM to form a nanofiber comprising the TGase and the cross-linkable protein polymer.
(FR) La présente invention concerne une nanofibre comprenant un polymère de protéine réticulable et une transglutaminase. La présente invention concerne également un procédé de production d'une nanofibre, le procédé consistant à : combiner une première solution comprenant un polymère de protéine réticulable et une seconde solution comprenant une transglutaminase pour produire un mélange d’électrofilage liquide (LEM) caractérisé par un environnement qui n'est pas adapté à l’activité enzymatique de la transglutaminase sur le polymère de protéine réticulable ; et électrofiler le LEM pour former une nanofibre comprenant la TGase et le polymère de protéine réticulable.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)