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1. (WO2019003150) COMBINATION AND USES AND TREATMENTS THEREOF
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Pub. No.: WO/2019/003150 International Application No.: PCT/IB2018/054769
Publication Date: 03.01.2019 International Filing Date: 27.06.2018
IPC:
A61K 9/20 (2006.01) ,A61K 31/5383 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5375
1,4-Oxazines, e.g. morpholine
5383
ortho- or peri-condensed with heterocyclic ring systems
Applicants:
VIIV HEALTHCARE COMPANY [US/US]; 251 Little Falls Drive Wilmington, DE 19808, US
JANSSEN SCIENCES IRELAND UNLIMITED COMPANY [IE/IE]; Barnahely, Ringaskiddy Co Cork, IE
Inventors:
CAMPBELL, Kenneth Churchill; GB
DELAET, Urbain Alfons C.; BE
GOODRICH, James M.; null
GUAQUIÈRE, Juliette Segolène; GB
LAUGHERY, Thomas; US
LIMET, Dominique J.; GB
POTTAGE, John C.; US
RENOU, Ludovic Sylvain Marc; GB
SCOTT, Trevor R.; US
SEILER, Christian; GB
WOODWARD, Mary; GB
Priority Data:
1717131.518.10.2017GB
1719377.222.11.2017GB
1806490.720.04.2018GB
62/527,16930.06.2017US
62/535,29021.07.2017US
62/589,57622.11.2017US
Title (EN) COMBINATION AND USES AND TREATMENTS THEREOF
(FR) ASSOCIATION, UTILISATIONS ET SCHÉMAS THÉRAPEUTIQUES
Abstract:
(EN) Methods are provided for treating or preventing human immunodeficiency virus-1 (HIV-1) or human immunodeficiency virus-2 (HIV-2) in a virologically suppressed patient in need thereof comprising switching the patient from an antiretroviral treatment regimen comprising at least three antiretroviral agents to a treatment regimen comprising only two antiretroviral agents. In one aspect the two treatment regimen consists of dolutegravir, rilpivirine and at least one pharmaceutically acceptable excipient, diluent or carrier. In another aspect of the invention, there is provided a multilayer tablet comprising dolutegravir or a pharmaceutically acceptable salt thereof and rilpivirine or a pharmaceutically acceptable salt thereof.
(FR) L'invention concerne des méthodes de traitement ou de prévention du virus de l'immunodéficience humaine 1 (VIH-1) ou du virus de l'immunodéficience humaine 2 (VIH-2) chez un patient non virémique en ayant besoin, comprenant le passage du patient d'un schéma thérapeutique antirétroviral comprenant au moins trois agents antirétroviraux à un schéma thérapeutique ne comprenant que deux agents antirétroviraux. Selon un aspect, le schéma thérapeutique consiste en dolutégravir, rilpivirine et au moins un excipient, diluant ou véhicule pharmaceutiquement acceptable. Selon un autre aspect de l'invention, un comprimé multicouche comprenant le dolutégravir ou un sel pharmaceutiquement acceptable de celui-ci et la rilpivirine ou un sel pharmaceutiquement acceptable de celle-ci est en outre décrit.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)