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1. (WO2019002887) NOVEL TREATMENTS
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Pub. No.: WO/2019/002887 International Application No.: PCT/GB2018/051842
Publication Date: 03.01.2019 International Filing Date: 29.06.2018
IPC:
A61K 38/17 (2006.01) ,G01N 33/00 (2006.01) ,A61P 25/16 (2006.01) ,A61P 25/28 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
14
for treating abnormal movements, e.g. chorea, dyskinesia
16
Anti-Parkinson drugs
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants:
UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWS [GB/GB]; College Gate North Street St Andrews KY16 9AJ, GB
Inventors:
THOMPSON, Luke William; GB
MORRISON, Kimberley Dawn; GB
SHIRRAN, Sally Lorna; GB
BOTTING, Catherine Helen; GB
SLEEMAN, Judith Elizabeth; GB
Agent:
MARKS & CLERK LLP; Aurora 120 Bothwell Street Glasgow G2 7JS, GB
Priority Data:
1710433.229.06.2017GB
Title (EN) NOVEL TREATMENTS
(FR) NOUVEAUX TRAITEMENTS
Abstract:
(EN) The present invention is based on the finding that the essential neural protein, neurochondrin (NCDN), interacts with the Survival Motor Neurone (SMN) protein. In neurodegenerative disorders, novel interactions such as this provide new insights into disease pathology and/or additional or alternate therapeutic options. Thus the disclosure provides neurochondrin (NCDN) modulators for use in the treatment and/or prevention of a neurodegenerative disorder.
(FR) La présente invention est basée sur la découverte selon laquelle la protéine neuronale essentielle, la neurochondrine (NCDN), interagit avec la protéine de survie du motoneurone (SMN). Dans les troubles neurodégénératifs, de nouvelles interactions comme celle-ci fournissent de nouvelles connaissances associées à une pathologie de maladie et/ou des options thérapeutiques supplémentaires ou alternatives. Ainsi, l'invention concerne des modulateurs de la neurochondrine (NCDN) destinés à être utilisés pour le traitement d'un trouble neurodégénératif et/ou pour la prévention de ce dernier.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)