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1. (WO2019002862) NANOPARTICLES FORMED OF A POLYMER AND TERBINAFINE
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Pub. No.: WO/2019/002862 International Application No.: PCT/GB2018/051802
Publication Date: 03.01.2019 International Filing Date: 28.06.2018
IPC:
A61K 31/137 (2006.01) ,A61K 9/00 (2006.01) ,A61P 31/10 (2006.01) ,A61K 9/12 (2006.01) ,A61M 11/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
135
having aromatic rings, e.g. methadone
137
Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
10
Antimycotics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
12
Aerosols; Foams
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
M
DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
11
Sprayers or atomisers specially adapted for therapeutic purposes
Applicants:
BLUEBERRY THERAPEUTICS LIMITED [GB/GB]; The Biohub Alderley Park, Alderley Edge Macclesfield, Cheshire SK10 4TG, GB
Inventors:
RIDDEN, John; GB
RIDDEN, Christine Caroline; GB
COOK, David; GB
COOK, Julie; GB
Agent:
APPLEYARD LEES IP LLP; 15 Clare Road Halifax Yorkshire HX1 2HY, GB
Priority Data:
1710491.030.06.2017GB
Title (EN) NANOPARTICLES FORMED OF A POLYMER AND TERBINAFINE
(FR) NANOPARTICULES FORMÉES À PARTIR D'UN POLYMÈRE ET DE TERBINAFINE
Abstract:
(EN) The present invention relates to a composition for use in the treatment of onychomycosis and/or tinea pedis, the composition comprising a polymer capable of forming nanoparticles and terbinafine, or derivative or salt thereof, wherein the nanoparticles are formed with and/or in the presence of terbinafine, or derivative or salt thereof and wherein the composition is administered topically to provide a daily dose to an infected area in the range of about 5μg to about 50μg of terbinafine. The invention also relates to a combination of the composition and a liquid dispensing device for dispensing a pre-defined quantity of the composition to a user's toes and/or inter-digital spaces and/or front of the foot.
(FR) La présente invention concerne une composition destinée à être utilisée dans le traitement de l'onychomycose et/ou du pied d'athlète, cette composition comprenant un polymère capable de former des nanoparticules et de la terbinafine, ou un dérivé ou sel de celle-ci, les nanoparticules étant formées à l'aide et/ou en présence de la terbinafine, ou du dérivé ou sel de celle-ci et la composition étant administrée par voie topique pour fournir une dose quotidienne à une zone infectée dans la plage d'environ 5 à environ 50 μg de terbinafine. Une combinaison de la composition et d'un dispositif de distribution de liquide pour distribuer une quantité prédéfinie de la composition aux orteils d'un utilisateur et/ou à des espaces interdigitaux et/ou à l'avant du pied est en outre décrite.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)