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1. (WO2019002678) A MICROFLUIDIC CHIP AND A METHOD FOR THE MANUFACTURE OF A MICROFLUIDIC CHIP
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Pub. No.: WO/2019/002678 International Application No.: PCT/FI2018/050492
Publication Date: 03.01.2019 International Filing Date: 25.06.2018
IPC:
B01L 3/00 (2006.01) ,B81C 1/00 (2006.01) ,B81C 3/00 (2006.01) ,G01F 11/28 (2006.01) ,G01N 33/543 (2006.01) ,G01N 35/00 (2006.01)
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
L
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3
Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
B PERFORMING OPERATIONS; TRANSPORTING
81
MICRO-STRUCTURAL TECHNOLOGY
C
PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICRO-STRUCTURAL DEVICES OR SYSTEMS
1
Manufacture or treatment of devices or systems in or on a substrate
B PERFORMING OPERATIONS; TRANSPORTING
81
MICRO-STRUCTURAL TECHNOLOGY
C
PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICRO-STRUCTURAL DEVICES OR SYSTEMS
3
Assembling of devices or systems from individually processed components
G PHYSICS
01
MEASURING; TESTING
F
MEASURING VOLUME, VOLUME FLOW, MASS FLOW, OR LIQUID LEVEL; METERING BY VOLUME
11
Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
28
with stationary measuring chambers having constant volume during measurement
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
543
with an insoluble carrier for immobilising immunochemicals
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
35
Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/-G01N33/148; Handling materials therefor
Applicants:
TEKNOLOGIAN TUTKIMUSKESKUS VTT OY [FI/FI]; Vuorimiehentie 3 02150 Espoo, FI
Inventors:
MAANINEN, Tiina; FI
KOKKONEN, Annukka; FI
KURKINEN, Marika; FI
AIKIO, Sanna; FI
Agent:
SEPPO LAINE OY; Itämerenkatu 3 A 00180 Helsinki, FI
Priority Data:
2017563730.06.2017FI
Title (EN) A MICROFLUIDIC CHIP AND A METHOD FOR THE MANUFACTURE OF A MICROFLUIDIC CHIP
(FR) PUCE MICROFLUIDIQUE ET PROCÉDÉ DE PRODUCTION D'UNE PUCE MICROFLUIDIQUE
Abstract:
(EN) A novel microfluidic chip is proposed for performing a chemical or biochemicaltest in a metered reaction volume (32). The microfluidic chip (100) has a body (200) which defines an inner flow volume. An inlet (10) has been provided to the body (200) for connecting the inner flow volume to the ambient space. A waste channel (20) forms part of the inner flow volume and is in fluid communication with the inlet (10). A sample channel (30) also forms part of the inner flow volume and is in fluid communication with the inlet (10). The sample channel (30) includes a first hydrophobic stop (61)and a second hydrophobic stop (62) at a distance from the first hydrophobic stop (61) so as to provide a metered reaction volume (32) there between. An expelling channel (40) is in fluid communication with the metered reaction volume (32) of the sample channel (30) through the first hydrophobic stop (61). A sample reservoir (51) is in fluid communication with the metered reaction volume (32) of the sample channel (30) through the second hydrophobic stop (62).
(FR) Une nouvelle puce microfluidique est proposée pour effectuer un test chimique ou biochimique dans un volume de réaction dosé (32). La puce microfluidique (100) a un corps (200) qui définit un volume d'écoulement interne. Une entrée (10) a été fournie au corps (200) pour relier le volume d'écoulement interne à l'espace ambiant. Un canal de déchets (20) fait partie du volume d'écoulement interne et est en communication fluidique avec l'entrée (10). Un canal d'échantillon (30) fait également partie du volume d'écoulement interne et est en communication fluidique avec l'entrée (10). Le canal d'échantillon (30) comprend une première butée hydrophobe (61) et une seconde butée hydrophobe (62) à une certaine distance de la première butée hydrophobe (61) de façon à fournir un volume de réaction dosé (32) entre celles-ci. Un canal d'expulsion (40) est en communication fluidique avec le volume de réaction dosé (32) du canal d'échantillon (30) à travers la première butée hydrophobe (61). Un réservoir d'échantillon (51) est en communication fluidique avec le volume de réaction dosé (32) du canal d'échantillon (30) à travers la seconde butée hydrophobe (62).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)