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1. (WO2019002608) FLUID SYSTEM FOR PRODUCING EXTRACELLULAR VESICLES AND ASSOCIATED METHOD
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Pub. No.: WO/2019/002608 International Application No.: PCT/EP2018/067704
Publication Date: 03.01.2019 International Filing Date: 29.06.2018
IPC:
C12M 1/12 (2006.01) ,C12M 1/06 (2006.01) ,C12M 1/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1
Apparatus for enzymology or microbiology
12
with sterilisation, filtration, or dialysis means
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1
Apparatus for enzymology or microbiology
04
with gas introduction means
06
with agitator, e.g. impeller
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1
Apparatus for enzymology or microbiology
Applicants:
UNIVERSITE PARIS DIDEROT PARIS 7 [FR/FR]; 5, rue Thomas Mann 75013 PARIS, FR
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) [FR/FR]; 3, rue Michel Ange 75016 PARIS, FR
GENETHON [FR/FR]; 1 Bis, rue de l'Internationale 91000 EVRY, FR
Inventors:
GAZEAU, Florence; FR
SILVA, Amanda Karine Andriola; FR
MERTEN, Otto-Wilhelm; FR
WILHELM, Claire; FR
PIFFOUX, Max; FR
Agent:
REGIMBEAU; 20, rue de Chazelles 75847 PARIS CEDEX 17, FR
Priority Data:
175618330.06.2017FR
Title (EN) FLUID SYSTEM FOR PRODUCING EXTRACELLULAR VESICLES AND ASSOCIATED METHOD
(FR) SYSTEME FLUIDIQUE DE PRODUCTION DE VESICULES EXTRACELLULAIRES ET PROCEDE ASSOCIE
Abstract:
(EN) The invention relates to a fluid system for producing extracellular vesicles from producing cells, comprising at least one container, a liquid medium contained by the container and producer cells, characterised in that it also comprises microcarriers suspended in the liquid medium, the majority of the producer cells being adherent to the surface of the microcarriers, and a liquid medium agitator, the agitator and the dimensions of the container being capable of controlling a turbulent flow of the liquid medium in the container.
(FR) L'invention concerne un système fluidique de production de vésicules extracellulaires à partir de cellules productrices, comprenant au moins un récipient, un milieu liquide contenu par le récipient et des cellules productrices, caractérisé en ce qu'il comprend également des microporteurs en suspension dans le milieu liquide, la majorité des cellules productrices étant adhérentes à la surface des microporteurs, et un agitateur de milieu liquide, l'agitateur et les dimensions du récipient étant adaptés à commander un écoulement turbulent du milieu liquide dans le récipient.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: French (FR)
Filing Language: French (FR)