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1. (WO2019002581) IDENTIFICATION AND ELIMINATION OF DAMAGED AND/OR SENESCENT CELLS
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Pub. No.: WO/2019/002581 International Application No.: PCT/EP2018/067655
Publication Date: 03.01.2019 International Filing Date: 29.06.2018
IPC:
C12Q 1/6883 (2018.01)
[IPC code unknown for C12Q 1/6883]
Applicants:
FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III [ES/ES]; C/ Melchor Fernández Almagro, 3 28029 Madrid, ES
Inventors:
SERRANO MARUGAN, Manuel; ES
LLANOS GIRON, Susana; ES
CHAIB, Andy Selim; DE
Agent:
ELZABURU S.L.P.; C/Miguel Angel, 21 28010 Madrid, ES
Priority Data:
17382417.829.06.2017EP
Title (EN) IDENTIFICATION AND ELIMINATION OF DAMAGED AND/OR SENESCENT CELLS
(FR) IDENTIFICATION ET ÉLIMINATION DE CELLULES ENDOMMAGÉES ET/OU SÉNESCENTES
Abstract:
(EN) This invention relates to methods of detecting cells over-expressing of Programmed Death Ligand 2 (PD-L2), in particular, damaged and/or senescent cells, and the identification thereof. The invention also extends to the use of antagonists of Programmed Death Ligand 2 (PD-L2) and Programmed Cell Death Protein 1 (PD-1) interaction, or inhibitors of PD-1 or PD-L2 expression to eliminate damaged and/or senescent cells, which are involved in numerous pathologies and aging, and are also produced as a result of exposure to toxic substances.
(FR) La présente invention concerne des procédés de détection de cellules surexprimant le ligand de mort programmée 2 (PD-L2), en particulier des cellules endommagées et/ou sénescentes, et leur identification. L'invention concerne également l'utilisation d'antagonistes de l'interaction entre le ligand de mort programmée 2 (PD-L2) et la protéine de mort cellulaire programmée 1 (PD-1), ou d'inhibiteurs de l'expression de PD-1 ou de PD-L2, en vue d'éliminer des cellules endommagées et/ou sénescentes, qui sont impliquées dans de nombreuses pathologies et dans le vieillissement, et qui sont également produites en conséquence de l'exposition à des substances toxiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)